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Clinical Application of Oncolytic Viruses: A Systematic Review
International Journal of Molecular Sciences, 2020 Leveraging the immune system to thwart cancer is not a novel strategy and has been explored via cancer vaccines and use of immunomodulators like interferons.
Aman Chauhan
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Oncolytic viruses: adenoviruses
Virus Genes, 2017Tumor-selectively replicating (oncolytic) viruses are promising tools for therapy of solid cancers and have been initially developed to achieve potent tumor lysis with acceptable side effects on healthy tissue. However, in recent years, oncolytic viruses have been recognized as therapeutic vehicles exhibiting multipronged anti-tumoral activity.
Julia Niemann, Florian Kühnel
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MicroRNAs and oncolytic viruses
Current Opinion in Virology, 2015MicroRNAs regulate gene expression in mammalian cells and often exhibit tissue-specific expression patterns. Incorporation of microRNA target sequences can be used to control exogenous gene expression and viral tropism in specific tissues to enhance the therapeutic indices of oncolytic viruses expressing therapeutic transgenes. Continued development of
Autumn J, Ruiz, Stephen J, Russell
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Oncolytic viruses and immunity
Current Opinion in Immunology, 2018Initially, direct oncolysis was thought to be the sole mechanism through which oncolytic viruses (OVs) exert their anti-tumor effect, and the immune system was perceived as the major obstacle in oncolytic virotherapy. Over the last decade, there has been a lot of debate on whether the immune system is a friend or foe of OVs.
Shyambabu, Chaurasiya +2 more
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Evolution of oncolytic viruses
Current Opinion in Virology, 2015Owing to their replicative capacity, oncolytic viruses (OVs) can evolve under the action of natural selection. Reversion to virulence and recombination with wild-type strains may compromise OV safety, therefore requiring evolutionary risk assessment studies.
Rafael Sanjuán, Valery Z Grdzelishvili
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Infectious Diseases in Clinical Practice, 2009
Abstract Oncolytic virus therapy has been used for more than 50 years capitalizing on the properties of viruses to selectively kill or deliver genes to tumor cells. Viruses target tumor cells because the cells are growing and provide the biochemical machinery to facilitate virus replication, and many have deregulated the control measures that would ...
Jonathan Brammer, Ken S. Rosenthal
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Abstract Oncolytic virus therapy has been used for more than 50 years capitalizing on the properties of viruses to selectively kill or deliver genes to tumor cells. Viruses target tumor cells because the cells are growing and provide the biochemical machinery to facilitate virus replication, and many have deregulated the control measures that would ...
Jonathan Brammer, Ken S. Rosenthal
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Potentiation of the effect of oncolytic viruses
American Journal of Obstetrics and Gynecology, 19620 N c o L Y T I c viruses demonstrate the ability to invade and to destroy tumor cells. Continuing experiments with oncolytic viruses have been carried out in the laboratories of the Department of Obstetrics and Gynecology, College of Medicine, The Ohio State University, since March, 1953.
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Histone modifiers at the crossroads of oncolytic and oncogenic viruses
Molecular Therapy, 2022Sara A Murphy +2 more
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