Results 221 to 230 of about 1,862,769 (263)
Some of the next articles are maybe not open access.
Oncolytic Viruses and Cancer Immunotherapy
Current Oncology Reports, 2022Oncolytic viruses (OVs) exert their antitumor effect through selective killing of cancer cells and induction of host anti-tumor immunity. This review aims to summarize the recent and current trials with OVs for the treatment of lung cancer.Several OVs have been developed for the treatment of lung cancer including adenovirus, coxsackievirus B3, reovirus,
Jyoti, Malhotra, Edward S, Kim
openaire +2 more sources
Evolution of oncolytic viruses
Current Opinion in Virology, 2015Owing to their replicative capacity, oncolytic viruses (OVs) can evolve under the action of natural selection. Reversion to virulence and recombination with wild-type strains may compromise OV safety, therefore requiring evolutionary risk assessment studies.
Rafael Sanjuán, Valery Z Grdzelishvili
openaire +2 more sources
Future Oncology, 2021
Oncolytic virotherapy has currently emerged as a powerful therapeutic approach in cancer treatment. Although the history of using viruses goes back to the early 20th century, the approval of talimogene laherparepvec (T-VEC) in 2015 increased interest in ...
N. H. Goradel +6 more
semanticscholar +1 more source
Oncolytic virotherapy has currently emerged as a powerful therapeutic approach in cancer treatment. Although the history of using viruses goes back to the early 20th century, the approval of talimogene laherparepvec (T-VEC) in 2015 increased interest in ...
N. H. Goradel +6 more
semanticscholar +1 more source
Investigational New Drugs, 1999
Viruses capable of inducing lysis of malignant cells through their replication process are known as "oncolytic" viruses. Clinical trials in oncology have been performed with oncolytic viruses for nearly fifty years. Both systemic and intratumoral routes of administration have been explored.
openaire +2 more sources
Viruses capable of inducing lysis of malignant cells through their replication process are known as "oncolytic" viruses. Clinical trials in oncology have been performed with oncolytic viruses for nearly fifty years. Both systemic and intratumoral routes of administration have been explored.
openaire +2 more sources
Infectious Diseases in Clinical Practice, 2009
Abstract Oncolytic virus therapy has been used for more than 50 years capitalizing on the properties of viruses to selectively kill or deliver genes to tumor cells. Viruses target tumor cells because the cells are growing and provide the biochemical machinery to facilitate virus replication, and many have deregulated the control measures that would ...
Jonathan Brammer, Ken S. Rosenthal
openaire +1 more source
Abstract Oncolytic virus therapy has been used for more than 50 years capitalizing on the properties of viruses to selectively kill or deliver genes to tumor cells. Viruses target tumor cells because the cells are growing and provide the biochemical machinery to facilitate virus replication, and many have deregulated the control measures that would ...
Jonathan Brammer, Ken S. Rosenthal
openaire +1 more source
Progress of oncolytic viruses in sarcomas
Expert Review of Anticancer Therapy, 2012Oncolytic virotherapy has shown exciting promise for the treatment of many types of solid tumors. Pediatric sarcomas are an aggressive type of pediatric malignancy known to show limited responsiveness to current therapies, leading to unacceptably high morbidity and mortality.
Christina K, Lettieri +2 more
openaire +2 more sources
Oncolytic viruses in radiation oncology
Radiotherapy and Oncology, 2011Oncolytic viruses are investigational cancer treatments. They are currently being assessed as single agents or in combination with standard therapies such as external beam radiotherapy - a DNA damaging agent that is a standard of care for many tumour types.
Yann, Touchefeu +2 more
openaire +2 more sources
Oncolytic viruses and cancer therapy
Cytokine & Growth Factor Reviews, 2001In the hopes that a better understanding of cancer biology would allow for the development of novel, more effective therapeutics, a concerted effort over the past 20 years has focussed on the molecular mechanisms of cell growth control and tumorigenesis.
K L, Norman, F, Farassati, P W, Lee
openaire +2 more sources
Oncolytic viruses in the therapy of gliomas
Molecular Biology, 2012Despite the advances of modern medicine, malignant glioblastoma cure remains an elusive goal. Both the invasive nature and location in vital areas of the brain make this type of tumors difficult for surgical treatment, while the current adjuvant therapy is not as successful as expected.
N V, Gubanova +6 more
openaire +2 more sources
Therapy with oncolytic viruses: progress and challenges
Nature Reviews Clinical Oncology, 2023S. Shalhout +3 more
semanticscholar +1 more source