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Immunotherapeutic Potential of TGF-β Inhibition and Oncolytic Viruses.
Trends in immunology, 2020In cancer immunotherapy, a patient's own immune system is harnessed against cancer. Immune checkpoint inhibitors release the brakes on tumor-reactive T cells and, therefore, are particularly effective in treating certain immune-infiltrated solid tumors ...
C. Groeneveldt +4 more
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Oncolytic viruses—immunotherapeutics on the rise
Journal of Molecular Medicine, 2016The oncolytic virus (OV) field has entered an exciting period in its evolution in which our basic understanding of viral biology and anti-cancer potential are being actively translated into viable therapeutic options for aggressive malignancies. OVs are naturally occurring or engineered viruses that are able to exploit cancer-specific changes in ...
Brian A, Keller, John C, Bell
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Future Directions: Oncolytic Viruses
Clinical Lung Cancer, 2004Oncolytic viruses offer a promising new modality for cancer treatment. The strategy of this therapy is to develop viruses capable of selectively infecting and replicating in malignant tumor cells. Oncolytic viruses can spread and destroy malignant tumors without deleterious effects in normal tissues.
Liang, You +4 more
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Macrophages and their interactions with oncolytic viruses
Current Opinion in Pharmacology, 2015Macrophages are a highly plastic cell type and exhibit a range of defensive and regulatory functions in normal physiology. Phagocytic macrophages play an important role in defending against virus infection and they provide an important barrier that can limit the delivery of therapeutic viruses from the injection to the tumour.
Philip G, Jakeman +3 more
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Potentiation of the effect of oncolytic viruses
American Journal of Obstetrics and Gynecology, 19620 N c o L Y T I c viruses demonstrate the ability to invade and to destroy tumor cells. Continuing experiments with oncolytic viruses have been carried out in the laboratories of the Department of Obstetrics and Gynecology, College of Medicine, The Ohio State University, since March, 1953.
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Oncolytic Viruses: Whats Next?
Current Cancer Drug Targets, 2007Cancer is a complex disease that often eludes successful treatment due to its propensity to evolve or adapt in the face of current therapeutic regimes. It is reasonable to suggest that sophisticated therapeutics that can attack cancers in multiple, but targeted ways, will be necessary in order to improve current success rates.
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Histone modifiers at the crossroads of oncolytic and oncogenic viruses
Molecular Therapy, 2022Balveen Kaur +2 more
exaly
Tutorial: design, production and testing of oncolytic viruses for cancer immunotherapy
Nature ProtocolsS. Gujar +6 more
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