Results 251 to 260 of about 490,236 (289)

One-Carbon Metabolism

, 2016
One-carbon metabolism ultimately delivers one-carbon moiety (methyl group) to many biologic reactions, including nucleotide synthesis and biological methylation, that are needed to synthesize essential components of cells and tissues and to maintain body
Eunkyung Suh, Sang-Woon Choi, Simonetta Friso   +2 more
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One‐carbon metabolism and microbial pathogenicity

Molecular Oral Microbiology, 2023
AbstractOne‐carbon metabolism (OCM) pathways are responsible for several functions, producing a number of one‐carbon unit intermediates (formyl, methylene, methenyl, methyl) that are required for the synthesis of various amino acids and other biomolecules such as purines, thymidylate, redox regulators, and, in most microbes, folate.
Kendall S. Stocke, Richard J. Lamont
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Metabolic modulation of transcription: The role of one-carbon metabolism

Cell Chemical Biology, 2022
While it is well known that expression levels of metabolic enzymes regulate the metabolic state of the cell, there is mounting evidence that the converse is also true, that metabolite levels themselves can modulate gene expression via epigenetic modifications and transcriptional regulation.
Lin, Jung-Ming G., Kourtis, Savvas, Ghose, Ritobrata, Pardo Lorente, Natalia, Kubicek, Stefan, Sdelci, Sara   +5 more
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One-carbon metabolism and bipolar disorder

Australian & New Zealand Journal of Psychiatry, 2013
Objective: Folate is one of the most widely used nutraceuticals for the treatment of mood disorders. In this article, we review folate metabolism, its relationship with bipolar disorder, and its therapeutic potential.
Ji Hyun, Baek, Emily E, Bernstein, Andrew A, Nierenberg   +2 more
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Nutrition, one-carbon metabolism and arsenic methylation

Toxicology, 2021
Exposure to arsenic (As) is a major public health concern globally. Inorganic As (InAs) undergoes hepatic methylation to form monomethyl (MMAs)- and dimethyl (DMAs)-arsenical species, facilitating urinary As elimination. MMAsIII is considerably more toxic than either InAsIII or DMAsV, and a higher proportion of MMAs in urine has been associated with ...
Ahlam Abuawad, Anne K. Bozack, Roheeni Saxena, Mary V. Gamble   +3 more
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One-Carbon Metabolism and Lipid Metabolism in DOHaD

2018
The predisposing factors to lifestyle-associated diseases are established in the early period of life with underlying gene-environment interaction. Epigenetics is a chemical modification-based genetic mechanism that is affected by various nutritional factors.
Hideoki, Fukuoka, Takeo, Kubota
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An orthogonal metabolic framework for one-carbon utilization

Nature Metabolism, 2021
Metabolic engineering often entails concurrent engineering of substrate utilization, central metabolism and product synthesis pathways, inevitably creating interdependency with native metabolism. Here we report an alternative approach using synthetic pathways for C1 bioconversion that generate multicarbon products directly from C1 units and hence are ...
Alexander Chou, Seung Hwan Lee, Fayin Zhu, James M. Clomburg, Ramon Gonzalez   +4 more
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The role of H-NS in one carbon metabolism

Biochimie, 1994
The H-NS protein of Escherichia coli regulates the expression of genes involved in many general processes such as osmoregulation and virulence. More recently, H-NS was shown to exert an effect on ilvIH gene expression in conjunction with the leucine responsive regulatory protein (Lrp).
J R, Landgraf, M, Levinthal, A, Danchin
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Formate: The Neglected Member of One-Carbon Metabolism

Annual Review of Nutrition, 2016
Formate, the only non-tetrahydrofolate (THF)-linked intermediate in one-carbon metabolism, is produced in mammals from a variety of metabolic sources. It occurs in serum of adults at a concentration of approximately 30 μM. Its principal function lies as a source of one-carbon groups for the synthesis of 10-formyl-THF and other one-carbon intermediates;
Margaret E, Brosnan, John T, Brosnan
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Folates and one-carbon metabolism in plants and fungi

Phytochemistry, 1997
Folate-dependent pathways of one-carbon metabolism are essential for the synthesis of purines, formylmethionyl-tRNA, thymidylate, serine and methionine. These syntheses use a cellular source of one-carbon substituted, tetrahydrofolate polyglutamate derivatives which are the preferred substrates of most folate-dependent enzymes.
E A, Cossins, L, Chen
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