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One-Carbon Metabolism in Health and Disease [PDF]
Cell Metabolism, 2017 One-carbon (1C) metabolism, mediated by the folate cofactor, supports multiple physiological processes. These include biosynthesis (purines and thymidine), amino acid homeostasis (glycine, serine, and methionine), epigenetic maintenance, and redox defense.
Joshua D Rabinowitz, Gregory S Ducker
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One‐carbon metabolism and microbial pathogenicity
Molecular Oral Microbiology, 2023AbstractOne‐carbon metabolism (OCM) pathways are responsible for several functions, producing a number of one‐carbon unit intermediates (formyl, methylene, methenyl, methyl) that are required for the synthesis of various amino acids and other biomolecules such as purines, thymidylate, redox regulators, and, in most microbes, folate.
Kendall S. Stocke, Richard J. Lamont
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Metabolic modulation of transcription: The role of one-carbon metabolism
Cell Chemical Biology, 2022While it is well known that expression levels of metabolic enzymes regulate the metabolic state of the cell, there is mounting evidence that the converse is also true, that metabolite levels themselves can modulate gene expression via epigenetic modifications and transcriptional regulation.
Lin, Jung-Ming G. +5 more
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Serine and one-carbon metabolism in cancer
Nature Reviews Cancer, 2016The non-essential amino acid serine supports several metabolic processes that are crucial for the growth and survival of proliferating cells, including protein, amino acid and glutathione synthesis. As an important one-carbon donor to the folate cycle, serine contributes to nucleotide synthesis, methylation reactions and the generation of NADPH for ...
Ming Yang, Karen H. Vousden
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One-carbon metabolism and bipolar disorder
Australian & New Zealand Journal of Psychiatry, 2013Objective: Folate is one of the most widely used nutraceuticals for the treatment of mood disorders. In this article, we review folate metabolism, its relationship with bipolar disorder, and its therapeutic potential.
Ji Hyun, Baek +2 more
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Nutrition, one-carbon metabolism and arsenic methylation
Toxicology, 2021Exposure to arsenic (As) is a major public health concern globally. Inorganic As (InAs) undergoes hepatic methylation to form monomethyl (MMAs)- and dimethyl (DMAs)-arsenical species, facilitating urinary As elimination. MMAsIII is considerably more toxic than either InAsIII or DMAsV, and a higher proportion of MMAs in urine has been associated with ...
Ahlam Abuawad +3 more
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An orthogonal metabolic framework for one-carbon utilization
Nature Metabolism, 2021Metabolic engineering often entails concurrent engineering of substrate utilization, central metabolism and product synthesis pathways, inevitably creating interdependency with native metabolism. Here we report an alternative approach using synthetic pathways for C1 bioconversion that generate multicarbon products directly from C1 units and hence are ...
Alexander Chou +4 more
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One-Carbon Metabolism and Lipid Metabolism in DOHaD
2018The predisposing factors to lifestyle-associated diseases are established in the early period of life with underlying gene-environment interaction. Epigenetics is a chemical modification-based genetic mechanism that is affected by various nutritional factors.
Hideoki, Fukuoka, Takeo, Kubota
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One Carbon Metabolism and Cardio-Metabolic risk
Voice of Intellectual Man- An International Journal, 2017The One Carbon Metabolic Pathway can be defined as the “atlas of human biology” in which elevations in the level of the critical metabolite that is homocysteine levels, a type of a pro-inflammatory molecule of the pathway can act as an indicator for an array of complex disorders ranging from adverse pregnancy outcomes like recurrent pregnancy loss ...
Ketaki Chandiok, Rakash Ranjan Monda
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The role of H-NS in one carbon metabolism
Biochimie, 1994The H-NS protein of Escherichia coli regulates the expression of genes involved in many general processes such as osmoregulation and virulence. More recently, H-NS was shown to exert an effect on ilvIH gene expression in conjunction with the leucine responsive regulatory protein (Lrp).
J R, Landgraf, M, Levinthal, A, Danchin
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