Results 261 to 270 of about 20,326,114 (289)
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Interaction of folylpolyglutamates with enzymes in one-carbon metabolism
Archives of Biochemistry and Biophysics, 1989Of all the coenzymes, tetrahydrofolate exhibits the most structural diversity. The relationship of these structural forms to physiological function is under intense study by numerous research groups. In textbooks, tetrahydrofolate (tetrahydropteroylmonoglutamate) is shown as the coenzyme of one-carbon metabolism, but it has been known for several ...
V, Schirch, W B, Strong
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Folates and one-carbon metabolism in plants and fungi
Phytochemistry, 1997Folate-dependent pathways of one-carbon metabolism are essential for the synthesis of purines, formylmethionyl-tRNA, thymidylate, serine and methionine. These syntheses use a cellular source of one-carbon substituted, tetrahydrofolate polyglutamate derivatives which are the preferred substrates of most folate-dependent enzymes.
E A, Cossins, L, Chen
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The Role of One-Carbon Metabolism in Schizophrenia and Depression
Harvard Review of Psychiatry, 2007Physicians often check folate and cobalamin levels in patients with schizophrenia and depression. The reasons for this practice are reviewed, as well as implications for treatment.The physiology of the one-carbon cycle, involving folate, cobalamin, homocysteine, S-adenosyl-methionine, and methylene tetrahydrofolate reductase (MTHFR) is first reviewed ...
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Formate: The Neglected Member of One-Carbon Metabolism
Annual Review of Nutrition, 2016Formate, the only non-tetrahydrofolate (THF)-linked intermediate in one-carbon metabolism, is produced in mammals from a variety of metabolic sources. It occurs in serum of adults at a concentration of approximately 30 μM. Its principal function lies as a source of one-carbon groups for the synthesis of 10-formyl-THF and other one-carbon intermediates;
Margaret E, Brosnan, John T, Brosnan
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A Synthetic Alternative to Canonical One-Carbon Metabolism
ACS Synthetic Biology, 2017One-carbon metabolism is an ubiquitous metabolic pathway that encompasses the reactions transferring formyl-, hydroxymethyl- and methyl-groups bound to tetrahydrofolate for the synthesis of purine nucleotides, thymidylate, methionine and dehydropantoate, the precursor of coenzyme A.
Bouzon, Madeleine +7 more
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Relationships among biomarkers of one-carbon metabolism
Molecular Biology Reports, 2012One-carbon metabolism is a network of metabolic pathways, disruption of which has been associated with cancer and other pathological conditions. Biomarkers of these pathways include homocysteine (HCY), S-adenosylmethionine (SAM), and S-adenosylhomocysteine (SAH).
Will D, King +5 more
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Formaldehyde regulates one-carbon metabolism and epigenetics
Trends in GeneticsRecently, Pham et al. used an array of model systems to uncover a role for the enzyme methionine adenosyltransferase (MAT)-1A, which is mainly expressed in liver, in both sensing formaldehyde and regulating transcriptional responses that protect against it. This provides a new lens for understanding the effects of formaldehyde on gene regulation.
Long, Marcus J. C., Aye, Yimon
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[One-carbon Metabolism and Schizophrenia].
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 2016One-carbon metabolism is a process whereby folate transters one-carbon groups in a range of biological processes, including DNA methylation and homocysteine metabolism. We have focused on and examined the potential roles of this one-carbon metabolism in the pathology of schizophrenia.
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The impact of urban scale on carbon metabolism -- a case study of Hangzhou, China
Journal of Cleaner Production, 2021Chuyu Xia, Jiayu Shen, Jiayu Yang
exaly