Results 31 to 40 of about 341,624 (160)

Chromosomal Instability Causes Sensitivity to Polyamines and One-Carbon Metabolism

Metabolites, 2023
Aneuploidy, or having a disrupted genome, is an aberration commonly found in tumours but rare in normal tissues. It gives rise to proteotoxic stress as well as a stereotypical oxidative shift, which makes these cells sensitive to internal and ...
Anowarul Islam, Zeeshan Shaukat, David L. Newman, Rashid Hussain, Michael G. Ricos, Leanne Dibbens, Stephen L. Gregory   +6 more
doaj   +1 more source

Genetic markers of One-Carbon Metabolism Disorders in Schizophrenial

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2019
The paper presents the results of the literature review and the authors’ own studies of the association of several several single-nucleotide genetic polymorphisms (SNP), which affect one-carbon metabolism, with a risk of schizophrenia and the severity of
T. V. Zhilyaeva, A. S. Piatoikina, A. S. Blagonravova, G. E. Mazo   +3 more
doaj   +1 more source

Chromium induced neurotoxicity by altering metabolism in zebrafish larvae

Ecotoxicology and Environmental Safety, 2021
Background: Recently, both trivalent chromium Cr (III) and hexavalent chromium Cr (VI) have been reported to produce neurotoxicity. However, the underlying mechanisms of the neurotoxicity caused by different chemical valence of chromium remain unclear ...
Yawen Xu, Li Wang, Jun Zhu, Ping Jiang, Zhan Zhang, Lei Li, Qian Wu   +6 more
doaj   +1 more source

Folic acid, one-carbon metabolism & childhood cancer

Indian Journal of Medical Research, 2017
Folate has been studied in relation to many diseases, especially cancer. Although it has been postulated to exert a dual effect on development of cancer, its role remains to be clearly defined. Its effect on cancer is the result of gene-nutrient interaction between the genes in folate metabolic pathway and dietary folate ...
Moulik, Nirmalya Roy, Kumar, Archana, Agrawal, Suraksha   +2 more
openaire   +2 more sources

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

eLife, 2016
Mitochondrial dysfunction is associated with a spectrum of human disorders, ranging from rare, inborn errors of metabolism to common, age-associated diseases such as neurodegeneration.
Xiaoyan Robert Bao, Shao-En Ong, Olga Goldberger, Jun Peng, Rohit Sharma, Dawn A Thompson, Scott B Vafai, Andrew G Cox, Eizo Marutani, Fumito Ichinose, Wolfram Goessling, Aviv Regev, Steven A Carr, Clary B Clish, Vamsi K Mootha   +14 more
doaj   +1 more source

Glioma cells require one-carbon metabolism to survive glutamine starvation

Acta Neuropathologica Communications, 2021
Cancer cells optimize nutrient utilization to supply energetic and biosynthetic pathways. This metabolic process also includes redox maintenance and epigenetic regulation through nucleic acid and protein methylation, which enhance tumorigenicity and ...
Kazuhiro Tanaka, Takashi Sasayama, Hiroaki Nagashima, Yasuhiro Irino, Masatomo Takahashi, Yoshihiro Izumi, Takiko Uno, Naoko Satoh, Akane Kitta, Katsusuke Kyotani, Yuichi Fujita, Mitsuru Hashiguchi, Tomoaki Nakai, Masaaki Kohta, Yoichi Uozumi, Masakazu Shinohara, Kohkichi Hosoda, Takeshi Bamba, Eiji Kohmura   +18 more
doaj   +1 more source

One-Carbon Metabolism in Health and Disease [PDF]

Cell Metabolism, 2017
One-carbon (1C) metabolism, mediated by the folate cofactor, supports multiple physiological processes. These include biosynthesis (purines and thymidine), amino acid homeostasis (glycine, serine, and methionine), epigenetic maintenance, and redox defense.
Gregory S, Ducker, Joshua D, Rabinowitz
openaire   +2 more sources

O-GlcNAc signaling increases neuron regeneration through one-carbon metabolism in Caenorhabditis elegans

eLife
Cellular metabolism plays an essential role in the regrowth and regeneration of a neuron following physical injury. Yet, our knowledge of the specific metabolic pathways that are beneficial to neuron regeneration remains sparse. Previously, we have shown
Dilip Kumar Yadav, Andrew C Chang, Noa WF Grooms, Samuel H Chung, Christopher V Gabel   +4 more
doaj   +1 more source

FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans

Nature Communications, 2023
Flavin containing monooxygenase 2 (FMO-2) is known to increase lifespan under dietary restriction through incompletely understood mechanisms. Here the authors report that FMO-2 modifies tryptophan and methionine metabolic pathways to enhance stress ...
Hyo Sub Choi, Ajay Bhat, Marshall B. Howington, Megan L. Schaller, Rebecca L. Cox, Shijiao Huang, Safa Beydoun, Hillary A. Miller, Angela M. Tuckowski, Joy Mecano, Elizabeth S. Dean, Lindy Jensen, Daniel A. Beard, Charles R. Evans, Scott F. Leiser   +14 more
doaj   +1 more source

Alterations in One-Carbon Metabolism in Celiac Disease [PDF]

Nutrients, 2020
Celiac disease (CD) is an autoimmune enteropathy associated with alterations of metabolism. Metabolomics studies, although limited, showed changes in choline, choline-derived lipids, and methionine concentrations, which could be ascribed to alterations in one-carbon metabolism. To date, no targeted metabolomics analysis investigating differences in the
Rafael Martín-Masot, Natàlia Mota-Martorell, Mariona Jové, José Maldonado, Reinald Pamplona, Teresa Nestares   +5 more
openaire   +5 more sources