Results 41 to 50 of about 341,624 (160)
Cell Death and Disease, 2023 Anaplastic thyroid cancer (ATC) is one of the most aggressive tumors with an extremely poor prognosis. Based on the several biological features related to glutamine metabolism in ATC, we hypothesized glutaminolysis inhibition induces cell death in ATC ...
Yeseong Hwang +8 more
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One-carbon metabolism and ionizing radiation: a multifaceted interaction
Biomolecular Concepts, 2017 Ionizing radiation (IR) is a ubiquitous component of our environment and an important tool in research and medical treatment. At the same time, IR is a potent genotoxic and epigenotoxic stressor, exposure to which may lead to negative health outcomes ...
Miousse Isabelle R. +7 more
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One-Carbon Metabolism Nutrients, Genetic Variation, and Diabetes Mellitus [PDF]
Diabetes & Metabolism JournalDiabetes mellitus (DM) affects about 9.3% of the population globally. Hyperhomocysteinemia (HHcy) has been implicated in the pathogenesis of DM, owing to its promotion of oxidative stress, β-cell dysfunction, and insulin resistance.
Jie Zhu +4 more
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Virus-mediated hijack of one-carbon metabolism [PDF]
Nature Reviews Cancer, 2019 Wang et al. investigated the early metabolic changes associated with Epstein–Barr virus (EBV) infection of B cells, which may have implications for EBV-driven lymphomas.
openaire +2 more sources
MASLD: insights on the role of folate in hepatic lipid metabolism
Frontiers in NutritionMetabolic dysfunction-associated steatotic liver disease (MASLD) is also known as fatty liver disease associated with non-alcoholic fatty liver disease (NAFLD), which is a spectrum of chronic liver diseases characterized by steatosis, inflammation ...
Minlan Yang +4 more
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Journal of Nutrition & Intermediary Metabolism, 2016 Background: Increasing evidence has shown that an elevated a level of homocysteine (Hcy) in the blood is related to several diseases. Over the last few years, studies have demonstrated creatine (Cr) synthesis and Hcy formation are metabolically connected;
Rafael Deminice, Flávia Troncon Rosa
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More Than a Metabolic Enzyme: MTHFD2 as a Novel Target for Anticancer Therapy?
Frontiers in Oncology, 2020 The bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2) is a mitochondrial one-carbon folate metabolic enzyme whose role in cancer was not known until recently. MTHFD2 is highly expressed in embryos and a wide range of tumors but
Zhiyuan Zhu, Gilberto Ka Kit Leung
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Serine and one-carbon metabolism sustain non-melanoma skin cancer progression
Cell Death Discovery, 2023 Non-melanoma skin cancer (NMSC) is a tumor that arises from human keratinocytes, showing abnormal control of cell proliferation and aberrant stratification.
Angela Cappello +7 more
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Metabolic Potential of Cancer Cells in Context of the Metastatic Cascade
Cells, 2020 The metastatic cascade is a highly plastic and dynamic process dominated by cellular heterogeneity and varying metabolic requirements. During this cascade, the three major metabolic pillars, namely biosynthesis, RedOx balance, and bioenergetics, have ...
Mohaned Benzarti +4 more
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Targeting serine-glycine-one-carbon metabolism as a vulnerability in cancers
Biomarker Research, 2023 The serine-glycine-one-carbon (SGOC) metabolic pathway is critical for DNA methylation, histone methylation, and redox homeostasis, in addition to protein, lipid, and nucleotide biosynthesis.
Wei Sun +6 more
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