Results 61 to 70 of about 23,033 (265)

One-variable and multi-mariable calculus on a non-Archimedean field extension of the real numbers [PDF]

P-Adic Numbers, Ultrametric Analysis, and Applications, 2013
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

APPLICATION OF INFORMATION FUNCTIONS FOR THE ANALYSIS AND EFFECTIVENESS INCREASE OF THE TESTS IN HIGHER MATHEMATICS

Інформаційні технології і засоби навчання, 2014
The present paper studies the issue of effectiveness analysis of pedagogical tests based on calculation of information functions. The algorithms of computation and analysis of information function depending on the type of test item and the chosen model ...
Oleksandr A. Dykhovychnyi, Anna F. Dudko
doaj  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Simulation and motion study of mechanical integrator 3D model [PDF]

FME Transactions, 2019
A Mechanical Integrator is a mechanical device which can be used to obtain the continual integration of the input variable value. This paper explains the operational principles and discloses the simulation and motion study results of the mechanical ...
Popkonstantinovic Branislav, Stojicevic Misa, Jeli Zorana, Obradovic Milos, Dragos-Laurentiu Popa   +4 more
doaj  

Increasing Interpersonal Interactions in an Online Course: Does Increased Instructor E-mail Activity and a Voluntary In-Person Meeting Time Facilitate Student Learning?

Online Learning, 2018
Distance learning is expanding rapidly in universities. While theoretical and qualitative literature stress the critical role of effective interpersonal interactions in motivating students and facilitating learning in online environments, quantitative ...
Bianca Cung, Di Xu, Sarah Eichhorn
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Fractional and Integrable Perspectives on a Variable-Coefficient Semi-Discrete NLS Equation: Analytical Method and Engineering Applications

Fractal and Fractional
The method of deriving fractional-order differential equations using Riesz fractional-order calculus is a new breakthrough, and it is possible to use the inverse scattering transform (IST) to solve the analytical solutions of the derived equations ...
Sen Zhao, Sheng Zhang, Bo Xu
doaj   +1 more source

Prediction of Basic Math Course Failure Rate in the Physics, Meteorology, Mathematics, Actuarial Sciences and Pharmacy Degree Programs

Revista Electrónica Educare, 2014
This paper summarizes a study conducted in 2013 with the purpose of predicting the failure rate of math courses taken by Pharmacy, Mathematics, Actuarial Science, Physics and Meteorology students at Universidad de Costa Rica (UCR).
Luis Rojas-Torres
doaj   +1 more source