Results 131 to 140 of about 7,506,157 (312)

Pandemic paradox: How the COVID-19 crisis transformed vaccine hesitancy into a two-edged sword

Human Vaccines & Immunotherapeutics
The rapid development of COVID-19 vaccines was a landmark achievement that saved millions of lives. However, this success also intensified vaccine hesitancy, as misinformation, evolving public health guidelines, and growing distrust in institutions ...
Esteban Ortiz-Prado, Isaac A. Suárez-Sangucho, Jorge Vasconez-Gonzalez, Pablo A. Santillan-Roldán, Melisa Villavicencio-Gomezjurado, Camila Salazar-Santoliva, Andrea Tello-De-la-Torre, Juan S. Izquierdo-Condoy   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Workshop summary : One Health Zoonotic Disease Prioritization for Multi-Sectoral Engagement in Uganda, Kampala, Uganda March 2\u20133, 2017 [PDF]

To best address zoonotic disease challenges in Uganda as part of the Global Health Security Agenda, a zoonotic disease prioritization workshop was held during March 2\u20133, 2017, at the Imperial Royale Hotel in Kampala.

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Communicating and disseminating One Health: successes of the One Health European Joint Programme

The application of a One Health approach recognizes that human health, animal health, plant health and ecosystem health are intrinsically connected. Tackling complex challenges associated with foodborne zoonoses, antimicrobial resistance, and emerging ...
Juan Ferré, Lucía De, Imberechts, Hein, Poirier, Aurore C, Cantlay, Jennifer, Whitehouse, Jack, Horton, Daniel, L, van der Poel, Wim, H M, Poirier, Aurore, C., Sepe, Ludovico P., Ragione, Roberto La, Horton, Daniel L., Itier, David, Poirier, Aurore C., Poirier, Aurore C., La Ragione, Roberto, Jokelainen, Pikka, Horton, Daniel L, Caniça, Manuela, Busani, Luca, Van der Poel, Win H. M., Roest, Hendrik-Jan, Lindberg, Ann, Gavier-Widén, Dolores, van de Giessen, Arjen, van der Poel, Wim H M, Mantovani, Alberto, Kaesbohrer, Annemarie, Morabito, Stefano, Sepe, Ludovico, P., Callegari, Arnaud, Campling, Elaine, de Juan, Lucia, Artursson, Karin, Jestin, André, Mølbak, Kåre, Taylor, Emma, Sepe, Ludovico P, Roest, Hendrick-Jan, van der Poel, Wim H.M.   +38 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

WHO’s structured process for creating health-conducive environments in countries: insights and examples from the African region

Global Health Action
This paper presents the structured process developed by the World Health Organization (WHO) to systematically scale up actions in environment, climate change, and health at the country level.
Jennyfer Wolf, Cristina Vert, Blanche-Philomene Melanga Anya, Abdoulaye Mariama Baissa, Bruce Gordon, Melanie Bertram, Clement Lugala Peter Lasuba, Maria Neira, Adelheid Werimo Onyango, Bernard Amon Tomas, Annette Prüss   +10 more
doaj   +1 more source

Effect of Toxocara canis infection on liver and lung microbial flora diversity and composition in dogs

Parasite
Toxocariasis is a zoonotic parasitic disease that is widely prevalent in the world. Toxocara canis adults are parasitic in the small intestinal tract of canids, and the larvae migrate to the liver and lungs before reaching the final destination.
Wang Na, Sieng Soben, Liang Tian, Chen Ping, Xu Jingyun, Han Qian   +5 more
doaj   +1 more source

One Health surveillance of colistin-resistant Enterobacterales in Belgium and the Netherlands between 2017 and 2019 [PDF]

BACKGROUND: Colistin serves as the last line of defense against multidrug resistant Gram-negative bacterial infections in both human and veterinary medicine. This study aimed to investigate the occurrence and spread of colistin-resistant Enterobacterales
i-4-1-Health Study Group
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