Results 121 to 130 of about 7,506,157 (312)

More-than-One Health

, 2023
The call for a One Health approach that transcends species and disciplinary boundaries assumes that human and veterinary medicine are discrete, distinctive domains whose separation must be overcome to achieve health benefits for all.

core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Leading to a better world

, 2014
Ninety-two students and eighty-nine young professionals from 10 countries including Indonesia, Malaysia, Vietnam, Thailand, Philippines, Lao PDR, Cambodia, China, Nepal, and Myanmar participated in leadership training events outlined in this report.
Indonesia One Health Coordinating Network (INDOHUN)
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

One Health Landscape in Tennessee: Current Status, Challenges, and Priorities

Tennessee’s ecological diversity, spanning forests, farmland, and urban areas, provides an ideal foundation for applying the One Health approach, which integrates human, animal, and environmental health.
Walid Q. Alali, Dan Grove, Mary-Margaret A. Fill, Sonia Mongold, Jane Yackley, Katie Garman, Debra L. Miller, Wesley Crabtree, Emily Leonard, Ashley Morgan   +9 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The Case for Community‐Owned and ‐Managed Research and Community Health Assessments: Promotora‐Researchers’ Partnerships Generate Adaptive Health Evaluation Tools

Community Science
Federal and state health data sets often lack the granularity needed for medically underserved small towns. To address this, we conducted two community health assessment surveys in Knights Landing (KL), a rural agricultural town in California, to ...
W. L. J. Ho, S. Rodriguez, E. Pardo, J. Tang, D. Piñon, S. Somepalle, J. Kelty, S. Manukian, M. Wilson, J. Ontiveros, N. Deeb‐Sossa, A. Aranda, 2018 Knights Landing Promotora‐Researchers   +12 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Dual deletion of ugd and phoB Attenuates virulence and enhances vaccine potential in Aeromonas dhakensis

BMC Veterinary Research
Aeromonas dhakensis, an increasingly prevalent pathogen in tropical areas, presents significant risks to public health and the aquaculture industry. This research evaluates the virulence effects of ugd and phoB gene deletions.
Xuesong Li, Mengqi Wang, Liqing Chen, Haibo Gao, Yanrong Lin, Yukun Wu, Shuai Ye, Aodi Yi, Guiying Guo, Lixia Fan, Nuo Yang, Jifeng Zeng, Jiping Zheng   +12 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source