Results 111 to 120 of about 15,511,007 (297)

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo   +10 more
wiley   +1 more source

Early Spatial and Contextual Coding Deficits in Hippocampal CA1 Precede Performance Decline in an Alzheimer's Disease Model

open access: yesAdvanced Science, EarlyView.
Two‐photon calcium imaging in behaving 5xFAD mice reveals early CA1 coding deficits before behavioral decline. Task‐related place cell activity and splitter cell trajectory coding are impaired, with reduced retrospective dominance and greater prospective weighting.
Yimei Li   +8 more
wiley   +1 more source

Enhancing student engagement in online education: the role of self-regulation and teacher support in Zambia

open access: yesDiscover Education
This study examined the opportunities and difficulties of online learning in Zambia’s higher education system, emphasizing the effects of self-regulation as a mediator between teacher-scaffolded online interactions and student learning engagement ...
Daniel Kangwa   +3 more
doaj   +1 more source

Measuring Online Student Engagement in Higher Education: Scale Development, Validation, and Psychometric Properties [PDF]

open access: yes, 2022
Student engagement in online learning environments is of particular importance to successful learning experiences due to the unique features of online learning environments (e.g., physical distance, sense of isolation from peers and instructors ...
Turk, Murat
core  

Osseoperceptive EMG Feedback Improves Grasp Force Control in Myoelectric Prosthetic Hands

open access: yesAdvanced Science, EarlyView.
Osseoperception is explored as a non‐invasive pathway for delivering sensory feedback in myoelectric prosthetic control. By encoding the user's electromyographic (EMG) signal through bone‐conducted stimulation, this approach enables predictive grasp force regulation.
Cristian Felipe Blanco‐Diaz   +2 more
wiley   +1 more source

The effect of teaching, social, and cognitive presence on student engagement in online courses: a structural equation modelling approach

open access: yesActa Psychologica
Using the Community of Inquiry (CoI) framework, this study investigates the effects of teaching presence, social presence, and cognitive presence on student engagement in online courses.
Sultan Hammad Alshammari   +1 more
doaj   +1 more source

Conceptualising Emotional Engagement in an Online Asynchronous Forum

open access: yes
This study examined how students conceptualise their emotions when engaging in online asynchronous forums within a university course. With the move online in work and educational practices and the reduction in physical contact, the need to understand ...
Prestridge, S
core   +1 more source

Using Peer Assisted Learning to improve academic engagement and progression of first year online law students

open access: yes, 2021
The University of Southern Queensland’s online study environment continues to grow with over 16,000 students studying online. Pre-Covid-19, online enrolments typically represent around 67% of all students studying at USQ.
Hevers, James, Crowley-Cyr, Lynda
core  

Near‐Infrared Fluorescent PROTAC Enables Theranostic Imaging and Selective Tau Degradation in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren   +11 more
wiley   +1 more source

Cross-Regional Students’ Engagement and Teacher Relationships Across Online and In-School Learning

open access: yesEducation Sciences
This study examines how teacher–student relationships and school engagement change across online and in-school learning, based on the experiences of 105 cross-regional secondary vocational students in China.
Huiqi Hu, Yijun Wang, Wolfgang Jacquet
doaj   +1 more source

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