Results 201 to 210 of about 1,121,714 (299)

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Enhancing interpreting performance, engagement, and self-regulated learning through peer assessment: an attachment theory perspective. [PDF]

Front Psychol
Yang C, Hou S, Chen J.
europepmc   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

A Multilevel Network Peer Intervention Among Student Men Who Have Sex With Men Attending University: Protocol for an Implementation-Effectiveness Before-After Cohort Study.

JMIR Res Protoc
Xu J, Dai Z, Qiu Y, Wang L.
europepmc   +1 more source

Resilience-building in palliative care professionals: scoping review. [PDF]

BMJ Support Palliat Care
Yongpraderm S, Inpithuk P, Wongprom I.
europepmc   +1 more source

Halorotetin B, A Novel Terpenoid Compound Derived from Marine Ascidian, Suppresses Tumor Growth by Targeting the Cell Cycle Regulator UBE2C

Advanced Science, EarlyView.
Halorotetin B, a novel small‐molecule terpenoid identified from an edible marine ascidian, exhibits strong anti‐tumor activity both in vitro and in vivo through direct targeting UBE2C to induce tumor cell cycle arrest and then lead tumor cell senescence. As a newly discovered UBE2C inhibitor, Halorotetin B can serve as a novel potential cell senescence
Shanhao Han, Jianhui Li, Yuting Zhu, Penghui Liu, Yaoyao Zheng, Muchun He, Bo Dong   +6 more
wiley   +1 more source

RETRACTION: High-Frequency Ultrasound Evaluation of Morphea: Retrospective Analytical Study. [PDF]

Skin Res Technol
europepmc   +1 more source

Ohio haemorrhage quality improvement project: initial implementation of the Alliance for Innovation on Maternal Health (AIM) Hemorrhage Patient Safety Bundle. [PDF]

BMJ Open Qual
Jenkins K, Lorenz A, Menegay MC, Fredette J, Ezzeldin A, Antonini A, Lappen JR, Schneider P, Mayer D, Ghanem R.   +9 more
europepmc   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Measurement properties of assessment tools for affiliate stigma in parents of children with autism: a systematic review protocol. [PDF]

BMJ Open
Zhu M, Liu J, Xiao H, Shi F, Li K, Tao L.   +5 more
europepmc   +1 more source