Results 231 to 240 of about 1,121,714 (299)

Clinical usefulness of tools used for screening and measuring frailty in the ambulance and emergency department in older people: a scoping review protocol. [PDF]

BMJ Open
Magnusson C, Wahlstedt N, Östlundh L, Ekdahl AW, Hugelius K, Kurland L.   +5 more
europepmc   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

A Shear Thickening Colloidal Suspension Functioning via Progressive Impact Jamming with Persistent Lubrication Layer

Advanced Science, EarlyView.
An ionic liquid‐based shear‐thickening fluid (ILSTF) exhibits lubricated dynamics from strong shear thickening to impact‐triggered jamming. A persistent nanometric solvation layer around silica governs both the shear thickening saturation in rheology and jamming front propagation under dynamic impact compression.
Yiran Wu, Yifeng Yu, Yiqiu Zhao, Qin Xu, T. X. Yu, Xin Zhang, Jinglei Yang   +6 more
wiley   +1 more source

Voices beyond the margins: a protocol for a qualitative systematic review and meta-synthesis of Indigenous patients' experiences accessing mainstream healthcare services in Canada. [PDF]

BMJ Open
Damag S, Villanueva E, Damag N, Plante M, Steinke C, Middha S, Oster R, Chatsis A, Awosoga OA.   +8 more
europepmc   +1 more source

Genetic Control of Tissue Remodeling by a Non‐Coding SNP in ITGA8 Explains Carotenoid‐Based Color Polymorphism in Marine Mollusks

Advanced Science, EarlyView.
In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei, Wenzhu Peng, Zekun Huang, Bingye Yang, Yiyu Wu, Minzhen Han, Yi Wang, Bingling Peng, Guosheng Hu, Jiawei Hong, Guijia Liu, Linwei Nie, Yang Gan, Miaoqin Huang, Xuan Luo, Weiwei You, Wen Liu, Caihuan Ke   +17 more
wiley   +1 more source

A Collaborative Model to Meet the Wellness Needs of Graduate Medical Education Programs. [PDF]

J Grad Med Educ
Furnari M, Hollander-Rodriguez J, Rea M.
europepmc   +1 more source

Accelerated Discovery of Topological Conductors for Nanoscale Interconnects

Advanced Science, EarlyView.
Copper interconnects exhibit a sharp increase in resistivity at ultra‐scaled dimensions, threatening continued miniaturization of integrated circuits. The gapless surface states of topological semimetals provide conduction channels resistant to localization.
Alexander C. Tyner, William Rogers, Po‐Hsin Shih, Yi‐Hsin Tu, Gengchiau Liang, Hsin Lin, Ching‐Tzu Chen, James M. Rondinelli   +7 more
wiley   +1 more source

Development of a core outcome set for intraventricular haemorrhage (IVH) in preterm infants: a study protocol. [PDF]

BMJ Open
Dou H, Li Y, Li YX, Yang Y, Zhang Y, Wu J, Liu D, Mao Y, Shi J, Tang J, Xiong T.   +10 more
europepmc   +1 more source

SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics

Advanced Science, EarlyView.
ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods. To address this, we propose SpatialESD, a Spatial
Hongyan Cao, Gaiqin Liu, Jingyi Xia, Runle Chen, Tong Wang, Xiaoling Yang, Ruiling Fang, Yanhong Luo, Ping Zeng, Hongmei Yu, Yanbo Zhang, Yuehua Cui   +11 more
wiley   +1 more source

Can a digital intervention 'Momentum' improve social functioning and transdiagnostic symptoms for Australian youth at ultrahigh risk for psychosis? Protocol for a superiority randomised controlled trial comparing treatment as usual with and without Momentum. [PDF]

BMJ Open
Mangelsdorf SN, Cagliarini D, Nelson B, McEnery C, Whiting J, Chinnery G, Valentine L, Lee YY, Mihalopoulos C, Liu V, Bendall S, Koval P, D'Alfonso S, Gonzalez-Blanch C, Ryan RM, Lederman R, H Lim M, McGorry P, Polari A, Yung A, Penn DL, Killackey E, Gleeson J, Alvarez-Jimenez M.   +23 more
europepmc   +1 more source