Results 321 to 330 of about 229,442 (394)

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Correction: Anxiety of microbially synthesized Fe3O4-SPIONs on embryonic/larval ontogeny in red tilapia (Oreochromis sp.). [PDF]

Appl Microbiol Biotechnol
Abouelkheir SS, Mourad MM.
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Overcoming polymorphism: a revised list of shell characters for the phylogenetic analysis of soft-shelled turtles (<i>Pan-Trionychidae</i>). [PDF]

Swiss J Palaeontol
Joyce WG.
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The ontogeny of circadian clock gene expression during mouse fetal development. [PDF]

Biochem Biophys Rep
Stanton DL, Zhu L, Hansen PJ.
europepmc   +1 more source

Unraveling hematopoietic stem cell ontogeny through single-cell multi-omics approaches. [PDF]

Front Cell Dev Biol
Jia Y, Huo S, Wu F, Song N, Li M.
europepmc   +1 more source

Vertebral microstructure marks the emergence of pelagic ichthyosaurs soon after the End Permian Mass Extinction. [PDF]

Sci Rep
Delsett LL, Faure-Brac MG, Engelschiøn VS, Houssaye A, Chinsamy A, Hurum JH, Kear BP.   +6 more
europepmc   +1 more source

Physiologically-Based Pharmacokinetics and Empirical Pharmacodynamic Modeling for Pediatric Henagliflozin Dosing: Clinical Insights for Chinese Patients. [PDF]

Pediatr Diabetes
Zhang X, Xue H, Xu J, Ren K, Qian F, Zhang Y, Dou J, Shen K, Zhu X, Xiang X, He Q.   +10 more
europepmc   +1 more source