Results 101 to 110 of about 1,266,792 (389)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
AmiGO: online access to ontology and annotation data
Bioinform., 2008 AmiGO is a web application that allows users to query, browse and visualize ontologies and related gene product annotation (association) data. AmiGO can be used online at the Gene Ontology (GO) website to access the data provided by the GO Consortium1 ...
S. Carbon +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Demo: A community based approach for managing ontology alignments [PDF]
, 2008 The Semantic Web is rapidly becoming a defacto distributed repository for semantically represented data, thus leveraging on the added on value of the network effect.
Alani, Harith +3 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Rethinking rules and social practices. The design of urban spaces in the post-Covid-19 lockdown
TeMA: Journal of Land Use, Mobility and Environment, 2020 In the last months a pandemic has changed the daily life of billions of people. Among the efforts to reduce the impact of the disease, social distancing has had huge consequences and raised may concerns, from the inadequacy of contemporary urban design ...
Maria Rosaria Stufano Melone +1 more
doaj +1 more source
A community based approach for managing ontology alignments [PDF]
, 2008 The Semantic Web is rapidly becoming a defacto distributed repository for semantically represented data, thus leveraging on the added on value of the network effect.
Alani, Harith +2 more
core +1 more source
, 2000 Trope ontology is exposed and confronted with the question where one trope ends and another begins. It is argued that tropes do not have determinate boundaries, it is arbitrary how tropes are carved up.
Faye, J. +3 more
core +1 more source
FEBS Open Bio, EarlyView.We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado +4 more
wiley +1 more source
, 2008 Increasingly, in data-intensive areas of the life sciences, experimental results are being described in algorithmically useful ways with the help of ontologies.
Barry Smith
core +2 more sources