Results 61 to 70 of about 176,433 (328)
Molecular Oncology, EarlyView.Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla +5 more
wiley +1 more source
Towards information profiling: data lake content metadata management [PDF]
, 2016 There is currently a burst of Big Data (BD) processed and stored in huge raw data repositories, commonly called Data Lakes (DL). These BD require new techniques of data integration and schema alignment in order to make the data usable by its consumers ...
Abelló Gamazo, Alberto +3 more
core +1 more source
Networked Ontologies with Contextual Alignments
Computing and Informatics, 2019 The problem of knowledge heterogeneity in the Semantic Web or in the context of information systems remains a major challenge for the scientific community, in particular when several ontologies developed independently and separately have to be exploited to exchange their knowledge.
Klai, Sihem +2 more
openaire +4 more sources
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Molecular Oncology, EarlyView.Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi +12 more
wiley +1 more source
Journal of Biomedical Semantics, 2012 Identifying relationships between hitherto unrelated entities in different ontologies is the key task of ontology alignment. An alignment is either manually created by domain experts or automatically by an alignment system.
Beisswanger Elena, Hahn Udo
doaj +1 more source
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
Reaching Agreement over Ontology Alignments [PDF]
, 2006 When agents communicate, they do not necessarily use the same vocabulary or ontology. For them to interact successfully, they must find correspondences (mappings) between the terms used in their respective ontologies. While many proposals for matching two agent ontologies have been presented in the literature, the resulting alignment may not be ...
Laera, Loredana +4 more
openaire +4 more sources
Molecular Oncology, EarlyView.RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha +10 more
wiley +1 more source
Alignment of ICNP® 2.0 Ontology and a proposed INCP® Brazilian Ontology
Revista Latino-Americana de Enfermagem, 2014 OBJECTIVE: to align the International Classification for Nursing Practice (ICNP®) Version 2.0 ontology and a proposed INCP® Brazilian Ontology.METHOD: document-based, exploratory and descriptive study, the empirical basis of which was provided by the ...
Carina Maris Gaspar Carvalho +3 more
doaj +1 more source