Results 81 to 90 of about 183,998 (331)

Evaluating the semantic web: a task-based approach [PDF]

, 2007
The increased availability of online knowledge has led to the design of several algorithms that solve a variety of tasks by harvesting the Semantic Web, i.e. by dynamically selecting and exploring a multitude of online ontologies.
A. Hotho, E. Motta, F. Giunchiglia, H. Alani, J. Hassell, J. Völker, L. Ding, L. Ding, L. Specia, N. Guarino, P. Buitelaar, R. Navigli, S. Bechhofer, T.D. Wang, W. Hage van, Z. Aleksovski   +15 more
core   +3 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Ontology Matching with CIDER: evaluation report for OAEI 2011 [PDF]

, 2011
CIDER is a schema-based ontology alignment system. Its algorithm compares each pair of ontology terms by, firstly, extracting their ontological contexts up to a certain depth (enriched by using lightweight inference) and, secondly, combining different ...
Bernad, J., Gracia del Río, Jorge, Mena, E.   +2 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Optimizing Ontology Alignment through Linkage Learning on Entity Correspondences

Complexity, 2021
Data heterogeneity is the obstacle for the resource sharing on Semantic Web (SW), and ontology is regarded as a solution to this problem. However, since different ontologies are constructed and maintained independently, there also exists the ...
Xingsi Xue, Chaofan Yang, Chao Jiang, Pei-Wei Tsai, Guojun Mao, Hai Zhu   +5 more
doaj   +1 more source

Algebraic Calculi for Weighted Ontology Alignments [PDF]

, 2016
Alignments between ontologies usually come with numerical attributes expressing the confidence of each correspondence. Semantics supporting such confidences must generalise the semantics of alignments without confidence. There exists a semantics which satisfies this but introduces a discontinuity between weighted and non-weighted interpretations ...
Inants, Armen, Atencia, Manuel, Euzenat, Jérôme   +2 more
openaire   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

MeLinDa: an interlinking framework for the web of data [PDF]

, 2011
The web of data consists of data published on the web in such a way that they can be interpreted and connected together. It is thus critical to establish links between these data, both for the web of data and for the semantic web that it contributes to ...
Euzenat, Jérôme, Scharffe, François
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Employing Ontology-Alignment and Locality-Sensitive Hashing to Improve Attribute Interoperability in Federated eID Systems

Complex Systems Informatics and Modeling Quarterly, 2016
Achieving interoperability, i.e. creating identity federations between different Electronic identities (eID) systems, has gained relevance throughout the past years.
Walter Priesnitz Filho, Carlos Ribeiro, Thomas Zefferer   +2 more
doaj   +1 more source