Results 71 to 80 of about 269,978 (302)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Ontology as mapping of material world
SHS Web of Conferences, 2018 This paper reviews currently available approaches and methods of automated population and enrichment of ontologies or ontology-based knowledge bases by structured data stored in various heterogeneous sources. Advantages and disadvantages of each approach
Leshcheva Irina, Leshchev Dmitry
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
How do Ontology Mappings Change in the Life Sciences? [PDF]
, 2012 Mappings between related ontologies are increasingly used to support data integration and analysis tasks. Changes in the ontologies also require the adaptation of ontology mappings.
Gross, Anika +3 more
core
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
The use of ontologies for effective knowledge modelling and information retrieval
Applied Computing and Informatics, 2018 The dramatic increase in the use of knowledge discovery applications requires end users to write complex database search requests to retrieve information.
Kamran Munir, M. Sheraz Anjum
doaj +1 more source
Towards ontology interoperability through conceptual groundings [PDF]
, 2008 . The widespread use of ontologies raises the need to resolve heterogeneities between distinct conceptualisations in order to support interoperability.
Dietze, Stefan, Domingue, John
core +2 more sources
Deciding Agent Orientation on Ontology Mappings [PDF]
, 2010 Effective communication in open environments relies on the ability of agents to reach a mutual understanding of the exchanged message by reconciling the vocabulary (ontology) used. Various approaches have considered how mutually acceptable mappings between corresponding concepts in the agents' own ontologies may be determined dynamically through ...
Doran, Paul +3 more
openaire +2 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source