Results 161 to 170 of about 1,139,414 (359)
Advanced Science, EarlyView.This study investigates the deacetylation of ACLY at K978 acts as a novel risk in colorectal cancer chemoresistance. The deacetylation of K978 induces ACLY relocation to the nucleus and promotes its binding to RBM15, a m6A methylation modification “writer”.
Jun Wen +8 more
wiley +1 more source
Automating Ontology Mapping in IT Service Management: A DOLCE and ITSMO Integration
Data Science JournalBackground: Ontologies and knowledge graphs have become critical for structuring data into machine-interpretable knowledge, especially in dynamic domains like IT service management (ITSM). Traditional ontology engineering relies heavily on domain experts,
Andrey Khalov, Olga Ataeva
doaj +1 more source
Advanced Science, EarlyView.This study reveals that Arabidopsis telomere repeat binding proteins (TRBs) form two closely related complexes. These complexes mediate H3K4me3 demethylation and transcriptional repression through a positive feedback loop and cooperate with PEAT and PRC2 complexes to regulate multiple histone modifications and gene expression across the genome ...
Qi Wang +7 more
wiley +1 more source
Breaking-down the Ontology Alignment Task with a Lexical Index and Neural Embeddings [PDF]
Large ontologies still pose serious challenges to state-of-the-art ontology alignment systems. In the paper we present an approach that combines a lexical index, a neural embedding model and locality modules to effectively divide an input ontology ...
Agibetov, A. +3 more
core
Advanced Science, EarlyView.This study uncovers a novel mechanism and therapeutic targets in obstetric antiphospholipid syndrome (OAPS). Antiphospholipid antibody/ß2‐glycoprotein I complex boosts CCL2 and TNF‐α expression in decidual macrophages via TLR4‐NF‐κB. CCL2 accumulates on endothelial surfaces via ACKR1, recruiting monocyte‐derived CCR2+ macrophages, driving inflammation,
Rui Gao +13 more
wiley +1 more source
An effective method of large scale ontology matching. [PDF]
J Biomed Semantics, 2014 Diallo G.
europepmc +1 more source
Advanced Science, EarlyView.By integrating single‐cell RNA sequencing and spatial transcriptomics, tenascin C (TNC) is unveiled as a central organizer of the proinflammatory and profibrotic niche in kidney fibrosis. TNC promotes macrophage activation through TLR4/NF‐κB signaling, leading to renal inflammation and fibrosis.
Li Li +14 more
wiley +1 more source
Advanced Science, EarlyView.This study establishes pharmacological microglial inhibition as a therapeutic strategy, demonstrating its capacity to remodel the lesion microenvironment through significant reduction of extracellular matrix deposition. This permissive environmental transformation facilitates robust regeneration of the reticulospinal tract, and reconstructs functional ...
Run Li +11 more
wiley +1 more source
A Multi-Agent Improved Semantic Similarity Matching Algorithm Based on Ontology Tree [PDF]
, 2012 Qian Gao, Young Im Cho
openalex +1 more source