Results 51 to 60 of about 38,633 (261)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Methodological Guidelines for Matching Ontologies
, 2011 Finding alignments between ontologies is a very important operation for ontology engineering. It allows for establishing links between ontologies, either to integrate them in an application or to relate developed ontologies to context. It is even more critical for networked ontologies.
Euzenat, Jérôme, Le Duc, Chan
openaire +2 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
MaF: An Ontology Matching Framework
, 2012 In this work, we present our experience when developing the Matching Framework (MaF), a framework for matching ontologies that allows users to configure their own ontology matching algorithms and it allows developers to perform research on new complex algorithms.
Martinez-Gil, Jorge +2 more
openaire +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Community-Driven Ontology Matching [PDF]
, 2006 We extend the notion of ontology matching to community-driven ontology matching. Primarily, the idea is to enable Web communities to establish and reuse ontology mappings in order to achieve, within those communities, an adequate and timely domain representation, facilitated knowledge exchange, etc.
Anna V. Zhdanova, Pavel Shvaiko
openaire +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
An Iterative Automatic Final Alignment Method in the Ontology Matching System
Journal of Information and Organizational Sciences, 2018 Ontology matching plays an important role in the integration of heterogeneous data sources that are described by ontologies. In order to determine correspondences between ontologies, a set of matchers can be used.
Marko Gulić +2 more
doaj +1 more source
Block Matching for Ontologies [PDF]
, 2006 Ontology matching is a crucial task to enable interoperation between Web applications using different but related ontologies. Today, most of the ontology matching techniques are targeted to find 1:1 mappings. However, block mappings are in fact more pervasive.
Wei Hu, Yuzhong Qu
openaire +1 more source