Results 131 to 140 of about 79,883 (298)
Precision therapies for genetic epilepsies in 2025: Promises and pitfalls
Epilepsia Open, EarlyView.Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang +3 more
wiley +1 more source
The C-terminal domain of Emi2 conjugated to cell-penetrating peptide activates mouse oocyte
Frontiers in Cell and Developmental BiologyIntroductionThe cell cycle of ovulated oocytes from various animal species, including mice, arrests at the second meiotic metaphase until fertilization. The meiotic cell cycle must be initiated to initiate embryonic development.
Toru Suzuki, Toru Suzuki
doaj +1 more source
In vitro maturation of germinal vesicle oocytes in stimulated intracytoplasmic sperm injection cycles [PDF]
, 2011 Objective: This study evaluated in vitro maturation (IVM) of oocytes in the germinal vesicle (GV) stage in stimulated intracytoplasmic sperm injection (ICSI) cycles.
Esmaelzadeh, S. +3 more
core
Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
Live birth following an innovative artificial oocyte activation protocol using double calcium stimulators. [PDF]
Chin Med J (Engl), 2023 Gao Y, Yang D, Fang Y, Wang X, Li D.
europepmc +1 more source
Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a [PDF]
, 2008 Acid-sensing ion channels are ligand-gated cation channels, gated by extracellular H+. H+ is the simplest ligand possible, and whereas for larger ligands that gate ion channels complex binding sites in the three-dimensional structure of the proteins have
Chen, Xuanmao +4 more
core +1 more source
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Intrauterine insemination (IUI) is a widely used first‐line fertility treatment, yet its success rates vary considerably. This review synthesizes evidence from peer‐reviewed studies published between 2000 and 2024, including randomized controlled trials, cohort and case–control studies, as well as systematic and narrative reviews identified ...
Kasuni Akalanka
wiley +1 more source
ART constraints imposed by the complexities of oocyte activation. [PDF]
J Assist Reprod Genet, 2022 Albertini DF.
europepmc +1 more source
Fertilization failure and oocyte activation.
The journal of medical investigation : JMI, 2000 Recent reports have suggested that when unfertilized oocytes with a spermatozoon after intracytoplasmic sperm injection (ICSI) are properly activated, the activated oocytes develop normally similar to fertilized oocytes. However, human oocytes do not easily respond to universal activators of mammalian oocytes like ethanol or calcium ionophore A23187 ...
Yamano, Shuji +3 more
openaire +1 more source
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Objective To compare the efficacy of the levonorgestrel‐releasing intrauterine system combined with metformin versus oral progestin combined with metformin in fertility‐preserving treatment for patients with atypical endometrial hyperplasia and early endometrial cancer, and to analyze related factors affecting efficacy.
Pengpeng Gu +5 more
wiley +1 more source