Results 111 to 120 of about 48,631 (292)

The Influence of Drosophila Spire and Myosin V During Mid‐Oogenesis Is Independent of Their Direct Interaction

Cytoskeleton, EarlyView.
ABSTRACT Cooperativity between cytoskeletal proteins is crucial for spatiotemporal coordination in biological processes, like oogenesis. In mammalian and Drosophila oogenesis, proper assembly and function of actin networks require coordination between actin assembly factors Spire and formins, as well as actin‐associated proteins like myosins and Rab ...
Joseph Y. Ong, Hannah M. Bailey, Emma Carley, Michelle Panzica, Merin Rixen, Neil Billington, Rong Liu, Margot E. Quinlan   +7 more
wiley   +1 more source

Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool [PDF]

, 2008
In the mammalian ovary, progressive activation of primordial follicles from the dormant pool serves as the source of fertilizable ova. Menopause, or the end of female reproductive life, occurs when the primordial follicle pool is exhausted.
Du, Chun, Peng, Stanford L., Shen, Yan, Tang, Wenli, Reddy, Pradeep, Lan, Zi-Jian, Peng, Stanford L, Cooney, Austin J, Lan, Zi Jian, Rajareddy, Singareddy, Jagarlamudi, Krishna, Jagarlamudi, Krishna,, Liu, Lian, Huhtaniemi, Ilpo, Liu, Kui,, Liu, Kui, Rajareddy, Singareddy,, Cooney, Austin J., Dubbaka Venu, Pradeep Reddy,, Adhikari, Deepak, Hämäläinen, Tuula, Adhikari, Deepak,   +21 more
core   +1 more source

Pronuclear formation by ICSI using chemically activated ovine oocytes and zona pellucida bound sperm

Journal of Animal Science and Biotechnology, 2016
Background In order to improve ICSI, appropiate sperm selection and oocyte activation is necessary. The objective of the present study was to determine the efficiency of fertilization using ICSI with chemically activated ovine oocytes and sperm selected ...
J. E. Hernández-Pichardo, Y. Ducolomb, S. Romo, M. E. Kjelland, R. Fierro, F. Casillas, M. Betancourt   +6 more
doaj   +1 more source

A shining starlet: Nematostella vectensis as a model for developmental, regenerative, and comparative biology

Developmental Dynamics, EarlyView.
Abstract The sea anemone, Nematostella vectensis, has been used as a model organism in developmental biology studies for many years. This estuarine species has the notable capacity to regenerate its full body plan from small pieces throughout life. Nematostella have been described as having a great degree of cellular plasticity.
Patrick A. Lewis, Zachary Horowitz, Michael Shribak, Karen Echeverri   +3 more
wiley   +1 more source

Inhibition of glycosphingolipid synthesis induces p34cdc2 activation in Xenopus oocyte [PDF]

, 1995
In Xenopus prophase-blocked oocytes, it is assumed that progesterone interacts with the plasma membrane to initiate a signalling cascade that ultimately leads to MPF activation.
Hélène Rime, Catherine Jessus, Ozon, René, De Smedt, Véronique, Jessus, Catherine, Véronique De Smedt, René Ozon, Rime, Hélène   +7 more
core   +1 more source

Add‐on treatment with vinpocetine reduces seizure frequency and improves comorbidities in patients with loss‐of‐function γ‐aminobutyric acid type A receptor variants

Epilepsia, EarlyView.
Abstract Objective The semisynthetic compound vinpocetine has gained attention as a potential precision medicine for developmental and epileptic encephalopathies caused by loss‐of‐function (LoF) variants in γ‐aminobutyric acid type A (GABAA) receptor genes. As a positive allosteric modulator of GABAA receptors, case reports suggest that vinpocetine can
Cathrine E. Gjerulfsen, Vivian W. Y. Liao, Tomasz S. Mieszczanek, Anne V. Jakobsen, Elena Gardella, Kern Olofsson, Marina Nikanorova, Allan Bayat, Sebastian Ortiz, Sarah Weckhuysen, Cecilie Johannessen Landmark, Orrin Devinsky, Mary Chebib, Philip K. Ahring, Guido Rubboli, Rikke S. Møller   +15 more
wiley   +1 more source

Endogenous KCNE Subunits Govern Kv2.1K+ Channel Activation Kinetics in Xenopus Oocyte Studies [PDF]

, 2006
Kv2.1 is a voltage-gated potassium (Kv) channel that generates delayed rectifier currents in mammalian heart and brain. The biophysical properties of Kv2.1 and other ion channels have been characterized by functional expression in heterologous systems ...
Gordon, Earl, Roepke, Torsten K., Abbott, G.W., Gordon, E., Abbott, Geoffrey W., Roepke, T.K.   +5 more
core   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Proliferative activity of oocytes in multi-oocyte follicles of bovine ovary

Semina: Ciências Agrárias, 2017
We characterized the proliferative activity of multi-oocyte follicles with anti-nuclear antigen of proliferating cells (PCNA). Ovaries (n = 12) from heifers were processed for histology. From 789 multi-oocytes follicles observed, only 11 were considered appropriated for immunostaining, since they presented all nuclei of the oocytes clearly visible. All
Reginaldo Luis Oliveira, Katia Cristina Silva-Santos, Suellen Miguez Gonzalez, Camila Bizarro-Silva, Fernanda Zandonadi Machado, Ana Paula Frederico Rodrigues Loureiro Bracarense, Marcelo Marcondes Seneda   +6 more
openaire   +4 more sources

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source