Results 121 to 130 of about 244,707 (368)

Multi‐Tissue Genetic Regulation of RNA Editing in Pigs

Advanced Science, EarlyView.
This study presents the first multi‐tissue map of RNA editing and its genetic regulation in pigs. By integrating RNA editing profiles, edQTL mapping, GWAS, and cross‐species comparisons, this work establishes RNA editing as a distinct regulatory layer linking genetic variation to complex traits, highlighting its functional and evolutionary significance.
Xiangchun Pan, Wentao Gong, Xiaodian Cai, Jinyan Teng, Jiali Cai, Haonan Zeng, Wondossen Ayalew, Qingpeng Shen, Zhanming Zhong, Yifei Wang, Wenjing Zhang, Yuhan Tian, Dantong Xu, Yahui Gao, Hongwei Yin, Yuebo Zhang, Jiahui Hou, Tianru Zhou, Jiaqi Li, Lingzhao Fang, Xiaolong Yuan, Zhe Zhang   +21 more
wiley   +1 more source

SIRT5–RAC2 Axis Drives Monocyte‐to‐Macrophage Differentiation to Promote Inflammatory Injury in Premature Ovarian Insufficiency

Advanced Science, EarlyView.
SIRT5 desuccinylates and stabilizes RAC2, activating CSF1R‐dependent signaling to drive monocyte differentiation into M0 macrophages and their polarization toward pro‐inflammatory M1 phenotypes in CTX‐induced premature ovarian insufficiency. Inhibiting the SIRT5‐RAC2 axis attenuates inflammation, reduces granulosa cell apoptosis, and preserves ...
Wenjing TanTai, Yaqi Li, Shengnan Liu, Minjuan Wu, Zhixiao Liu, Junfeng Jiang, Jingjing Chen, Xiaoding Xu, Li Li, Chaoqun Li, Fang Zhao, Ye Liu, Haitao Ni, Tengfei Zhang, Mingjuan Xu, Chaofeng Han   +15 more
wiley   +1 more source

Navigating conflict of interest in oocyte donation: an analysis of donors’ experiences [PDF]

, 2000
Andrea L. Kalfoglou, Gail Geller
openalex   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Survey of Third-Party Parenting Options Associated With Fertility Preservation Available to Patients With Cancer Around the Globe [PDF]

, 2017
Purpose: In the accompanying article, “Analysis of Fertility Preservation Options Available to Patients With Cancer Around the Globe,” we showed that specific fertility preservation services may not be offered at various sites around the world because of
Adiga, Satish Kumar, Almeida-Santos, Teresa, Anazodo, Antoinette, Andersen, Claus Yding, Anderson, Richard A., Antunes, Roberto de A., Arvas, Ayse, Ataman, Lauren M., Azambuja, Ricardo, Azmy, Osama, Beerendonk, Catharina C.M., Bourlon, Maria T., Campos-Junior, Paulo Henrique Almeida, Chehin, Maurício Barbour, de Roo, Saskia F., De Vos, Michel, del Mar Andrés, María, Diaz-Garcia, Cesar, Edmonds, Maxwell E., Fathi, Rouhollah, Ferreira Melo e Silva, Lígia Helena, Fontoura, Paula, Furui, Tatsuro, Greenblatt, Ellen M., Grieco, Silvana Chedid, Horbaczewska, Anna, Jach, Robert, Jayasinghe, Yasmin, Khrouf, Mohamed, Kim, Seok Hyun, Lee, Jung Ryeol, Mallmann, Peter, Marcos de Meneses e Silva, Joao, Marinho, Ricardo M., Medrano, Jose, Melo, Cláudia, Mitchell, Rod, Motta, Eduardo, Nelen, Willianne, Ramalho de Carvalho, Bruno, Rashedi, Alexandra S., Reis, Fernando M., Rodrigues, Jhenifer K., Romero, Sergio, Salama, Mahmoud, Sartorio, Cassio, Scarella, Anibal, Shaulov, Talya, Silva, Adelino Amaral, Smith, Kristin, Smitz, Johan, Sugishita, Yodo, Suh, Chang Suk, Suzuki, Nao, Sánchez, Flor, Takae, Seido, Terrado, Guillermo, Van Moer, Ellen, Vega, Mario, Wildt, Ludwig, Winkler-Crepaz, Katharina, Woodruff, Teresa K., Zand, Elnaz   +62 more
core   +3 more sources

Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9

Animal Models and Experimental Medicine, EarlyView.
We established the first conditional knockout (cKO) model in the golden Syrian hamster by CRISPR/Cas9‐mediated genome editing. Cas9 protein, two sgRNAs, and a donor plasmid carrying loxP‐flanked exon 2 of the ApoF gene were microinjected into one‐cell embryos. The floxed allele was efficiently generated (up to 27%) and transmitted through the germline.
Wei Chen, Xu Zhang, Rui Fan, Xia Li, Feifei Guan, Gefan Wan, Weining Kong, Xiaolong Qi, Shuo Pan, Sijing Shi, Yuanlong Su, Shan Gao, Wei Huang, Xunde Xian, Jiangning Liu, Yuhui Wang, Yuanwu Ma   +16 more
wiley   +1 more source

Customised Oocyte Donation Enhancement and New Findings Regarding the Role of Growth Hormone

European Medical Journal, 2018
In vitro fertilisation (IVF) with donated oocytes is the most effective assisted reproduction treatment currently available; however, repeated implantation failure (RIF) can occur with this treatment.
Jan Tesarik
doaj  

Early menopause: A hazard to a woman's health [PDF]

, 2017
Early menopause or premature ovarian insufficiency (POI) is a common cause of infertility in women and affects about one per cent of young women. This disorder has significant psychological sequelae and major health implications.
Castelo-Branco Flores, Camil, Hernández Angeles, Claudio   +1 more
core   +1 more source

Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice

Annals of Neurology, EarlyView.
A Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone body produced by the ketogenic diet, may mediate its ...
Soudabeh Naderi, John Williamson, Huayu Sun, Suchitra Joshi, Rachel Jane Spera, Savaira Zaib, Supriya Sharma, Chengsan Sun, Andrey Brodovskiy, Ifrah Zawar, Jaideep Kapur   +10 more
wiley   +1 more source

Pregnancy outcomes in women with primary ovarian insufficiency in assisted reproductive technology therapy: a retrospective study

Frontiers in Endocrinology
PurposeThis study aims to retrospectively estimate cumulative reproductive outcomes in women with primary ovarian insufficiency (POI) in assisted reproductive technology (ART) therapy.MethodsA total of 139 patients diagnosed with POI were reviewed in ...
Bo Sun, Lu Li, Yile Zhang, Fang Wang, Yingpu Sun   +4 more
doaj   +1 more source