Results 101 to 110 of about 420,620 (395)

SET Improved Oocyte Maturation by PP2A and Inhibited Oocyte Apoptosis in Mouse Oocytes

open access: yes, 2021
Abstract Background: SET is a multifunctional protein involved in a variety of molecular processes such as transcription control, chromatin remodeling, cell apoptosis, and cell-cycle regulation. In ovaries SET is predominantly expressed in theca cells and oocytes. And in PCOS patients the expression of SET was increased than normal people.
Lingling Gao   +4 more
openaire   +2 more sources

RSPO2 Coordinates with GDF9:BMP15 Heterodimers to Promote Granulosa Cell and Oocyte Development in Mice

open access: yesAdvanced Science, EarlyView.
RSPO2 and GDF9:BMP15 heterodimers—core components of oocyte‐secreted factors (OSFs)—coordinate to shape the molecular architecture of preantral granulosa cells via gene‐specific synergistic and antagonistic regulation, mediated through CTNNB1–SMAD2 signaling crosstalk.
Yingmei Wang   +7 more
wiley   +1 more source

Arachidonic Acid as a Possible Negative Feedback Inhibitor of Nicotinic Acetylcholine Receptors on Neurons [PDF]

open access: yes, 1995
Neuronal acetylcholine receptors, being highly permeable to calcium, are likely to regulate calcium-dependent events in neurons. Arachidonic acid is a membrane-permeant second messenger that can be released from membrane phospholipids by phospholipases ...
Berg, Darwin K.   +3 more
core   +2 more sources

Measurement of ATP in Single Oocytes: Impact of Maturation and Cumulus Cells on Levels and Consumption

open access: yesJournal of Cellular Physiology, 2014
Mitochondria provide the primary source of ATP in the oocyte and early embryo and mitochondrial dysfunction and deficit of mitochondria‐derived ATP has been linked to suboptimal developmental competence.
C. Dalton, G. Szabadkai, J. Carroll
semanticscholar   +1 more source

Regenerative Hair Pigmentation via Skin Organoids: Adaptive Patterning Mediated by Collagen VI and Semaphorin 3C

open access: yesAdvanced Science, EarlyView.
The release of COL6A3 by fibroblasts is sensed by the CD44 receptor on melanocytes, activating glutathione (GSH) metabolism and increasing melanocyte survival during skin organoid culture. SEMA3C released by bulge cells binds to the NRP1 receptor on melanocytes, regulating microtubule stability and promoting melanocyte recruitment and function during ...
Tingting Li   +17 more
wiley   +1 more source

Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level

open access: yeseLife, 2016
Mammalian oocytes are arrested in the dictyate stage of meiotic prophase I for long periods of time, during which the high concentration of the p53 family member TAp63α sensitizes them to DNA damage-induced apoptosis.
Daniel Coutandin   +15 more
doaj   +1 more source

Laser microdissection as a new approach to prefertilization genetic diagnosis [PDF]

open access: yes, 2000
The genetic status of oocytes can be determined by polar body (PB) analysis. Following PB extraction, a genetic evaluation is performed. As each PB contains the complementary genetic material of the oocyte, PB analysis reveals information about its ...
Buchholz, Tina   +2 more
core   +1 more source

Development in vitro of mouse oocytes from primordial follicles.

open access: yesBiology of Reproduction, 1996
The objective of these studies was to achieve complete oocyte development in vitro beginning with the oocytes in the primordial follicles of newborn mouse ovaries.
J. Eppig, M. O'Brien
semanticscholar   +1 more source

Oocyte-secreted factors enhance oocyte developmental competence

open access: yesDevelopmental Biology, 2006
The capacity of fully grown oocytes to regulate their own microenvironment by paracrine factors secreted by the oocyte (oocyte-secreted factors, OSFs) may in turn contribute to oocyte developmental competence. Here, we investigated if OSFs have a direct influence on oocyte developmental competence during in vitro maturation (IVM). Bovine cumulus-oocyte
Hussein, T., Thompson, J., Gilchrist, R.
openaire   +4 more sources

Intermediate Filament Protein BFSP1 Maintains Oocyte Asymmetric Division by Modulating Spindle Length

open access: yesAdvanced Science, EarlyView.
Different from mitosis, the female meiosis undergoes asymmetric division that produces haploid oocytes and polar body, which is essential for retaining maternal components to support subsequent fertilization and embryo development. However, the underlying mechanisms are still largely unknown.
Yu Li   +6 more
wiley   +1 more source

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