ABSTRACT Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder influenced by genetic, epigenetic, and environmental factors. ASD is characterized by a higher prevalence in males compared to females, highlighting the potential role of sex‐specific risk factors in its development.
Ju Sun Heo+4 more
wiley +1 more source
Telomere lengths in human oocytes, cleavage stage embryos and blastocysts [PDF]
Telomeres are repeated sequences that protect the ends of chromosomes and harbour DNA-repair proteins. Telomeres shorten during each cell division in the absence of telomerase.
Achi+42 more
core +2 more sources
Objetivou-se avaliar os efeitos da criopreservação pelo método convencional em ovócitos imaturos e maturados in vitro. Utilizou-se ovócitos provenientes de ovários de vacas abatidas em matadouro, distribuídos em seis tratamentos: ovócitos não-congelados ...
Letícia Martins Fagundes+4 more
doaj +1 more source
Advances in methodologies for quantifying protein–protein interactions in living cells
Measuring the binding affinities of protein–protein interactions (PPIs) is important for understanding underlying biological mechanisms. As methods for studying PPIs differ between in vitro and in‐cell conditions due to environmental differences, it is crucial to stay informed about recent trends and methodologies in both experimental contexts ...
Soojung Yi, Yejin Ahn, Nam Ki Lee
wiley +1 more source
Oocyte-secreted factors enhance oocyte developmental competence
The capacity of fully grown oocytes to regulate their own microenvironment by paracrine factors secreted by the oocyte (oocyte-secreted factors, OSFs) may in turn contribute to oocyte developmental competence. Here, we investigated if OSFs have a direct influence on oocyte developmental competence during in vitro maturation (IVM). Bovine cumulus-oocyte
Hussein, T., Thompson, J., Gilchrist, R.
openaire +4 more sources
PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential
ABSTRACT Centrosomes catalyze the assembly of a microtubule‐based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo‐Like Kinase 4 (PLK4), the master regulator that controls the duplication of the centriolar core to ensure the correct balance of two centrosomes per dividing ...
Muhammad Hamzah+2 more
wiley +1 more source
The MinK Potassium Channel Exists in Functional and Nonfunctional Forms When Expressed in the Plasma Membrane of \u3cem\u3eXenopus\u3c/em\u3e Oocytes [PDF]
The minK protein induces a slowly activating voltage-dependent potassium current when expressed in Xenopus oocytes. In order to measure the levels of minK protein in the plasma membrane, we have modified the minK gene by inserting a 9 amino acid epitope ...
Blumenthal, Edward M+1 more
core +1 more source
The NLS3 Motif in TPX2 Regulates Spindle Architecture in Xenopus Egg Extracts
ABSTRACT A bipolar spindle composed of microtubules and many associated proteins functions to segregate chromosomes during cell division in all eukaryotes, yet both spindle size and architecture vary dramatically across different species and cell types.
Guadalupe E. Pena+4 more
wiley +1 more source
Gene expression studies on bovine oocyytes and embryos subjected to various heat stress and heat shock conditions [PDF]
Tese de Doutoramento, Ciências Agrárias, 14 de junho de 2018, Universidade dos Açores.Increasing temperature mainly by global warming has been showing rapid environmental temperature chances, unpredictable climatic changes.
Pavani, Krishna Chaitanya
core
A Requirement for Fatty Acid Oxidation in the Hormone-Induced Meiotic Maturation of Mouse Oocytes [PDF]
We have previously shown that fatty acid oxidation (FAO) is required for AMP-activated protein kinase (PRKA)-induced maturation in vitro. In the present study, we have further investigated the role of this metabolic pathway in hormone-induced meiotic ...
Downs, Stephen, Valsangkar, Deepa
core +2 more sources