Results 61 to 70 of about 16,336,802 (316)

Are open‐Label Placebos Ethical? Informed Consent and Ethical Equivocations [PDF]

Bioethics, 2016
AbstractThe doctor‐patient relationship is built on an implicit covenant of trust, yet it was not until the post‐World War Two era that respect for patient autonomy emerged as an article of mainstream medical ethics. Unlike their medical forebears, physicians today are expected to furnish patients with adequate information about diagnoses, prognoses ...
Charlotte, Blease, Luana, Colloca, Ted J, Kaptchuk   +2 more
openaire   +2 more sources

If only they knew! A non‐inferiority randomized controlled trial comparing deceptive and open‐label placebo in healthy individuals

European Journal of Pain, 2023
Placebo use is widespread in clinical practice. However, they are most often administered deceptively rather than openly. It is often suggested that open‐label placebos (OLP) are less effective than deceptive placebos (DP).
L. Druart, S. E. Graham Longsworth, H. Terrisse, C. Locher, C. Blease, C. Rolland, N. Pinsault   +6 more
semanticscholar   +1 more source

Open-label Placebo Treatment in Chronic Low Back Pain: A Randomized Controlled Trial

Pain, 2016
This randomized controlled trial was performed to investigate whether placebo effects in chronic low back pain could be harnessed ethically by adding open-label placebo (OLP) treatment to treatment as usual (TAU) for 3 weeks.
Cláudia Carvalho, J. Caetano, Lidia Cunha, Paula Rebouta, T. Kaptchuk, I. Kirsch   +5 more
semanticscholar   +1 more source

Placebos without deception: a randomized controlled trial in irritable bowel syndrome. [PDF]

PLoS ONE, 2010
Placebo treatment can significantly influence subjective symptoms. However, it is widely believed that response to placebo requires concealment or deception.
Ted J Kaptchuk, Elizabeth Friedlander, John M Kelley, M Norma Sanchez, Efi Kokkotou, Joyce P Singer, Magda Kowalczykowski, Franklin G Miller, Irving Kirsch, Anthony J Lembo   +9 more
doaj   +1 more source

Open-label Placebos for Wound Healing: A Randomized Controlled Trial [PDF]

Annals of Behavioral Medicine, 2018
Open-label placebos are a novel treatment option, in which participants take placebos with full knowledge that they do not contain active medicine. Open-label placebo treatments have been shown to result in patient-reported symptom improvements, but they have not been tested on objectively measurable physiological outcomes such as wound healing.The ...
Ashwin, Mathur, Paul, Jarrett, Elizabeth, Broadbent, Keith J, Petrie   +3 more
openaire   +2 more sources

Why psychotherapy is an open-label placebo and open-label placebos are psychotherapy

, 2023
Abstract In recent years, placebos have undergone a rapid development from methodological chaff to therapeutic wheat. Hereby, the role of placebos as a deceptive control in clinical trials, as well as negative denomination for anything murky, changed to an innovative promise, an effective as well as ethical treatment.
openaire   +1 more source

Motor- and cognition-related safety of pimavanserin in patients with Parkinson's disease psychosis

Frontiers in Neurology, 2022
BackgroundPimavanserin, a selective 5-HT2A inverse agonist/antagonist, is the only treatment approved by the US Food and Drug Administration for hallucinations and delusions associated with Parkinson's disease (PD) psychosis.AimWe aimed to evaluate motor-
Victor Abler, Cecilia Brain, Clive Ballard, Ana Berrio, Bruce Coate, Alberto J. Espay   +5 more
doaj   +1 more source

Imaginary pills and open-label placebos can reduce test anxiety by means of placebo mechanisms

Scientific Reports, 2023
AbstractPlacebos have been shown to be beneficial for various conditions even if administered with full transparency. Hence, so-called open-label placebos (OLPs) offer a new way to harness placebo effects ethically. To take this concept one step further, this study aimed at evaluating placebo effects without the use of a physical placebo, i.e., by ...
Buergler, Sarah, Sezer, Dilan, Bagge, Niels, Kirsch, Irving, Locher, Cosima, Carvalho, Claudia, Gaab, Jens   +6 more
openaire   +5 more sources

Effects of Open-Label Placebos on State Anxiety and Glucocorticoid Stress Responses [PDF]

Brain Sciences, 2021
Stress belongs to the most frequent negative feelings people are confronted with in daily life. Strategies against acute stress include, e.g., relaxation techniques or medications, but it is also known that placebos can successfully reduce negative emotional stress.
Schaefer, Michael, Hellmann-Regen, Julian, Enge, Sören   +2 more
openaire   +3 more sources

A fictionalist account of open label placebo [PDF]

, 2022
The placebo effect is now generally defined widely as an individual’s response to the psychosocial context of a clinical treatment, as distinct from the treatment’s characteristic physiological effects.
Hardman, Doug
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