Results 51 to 60 of about 16,336,802 (316)

Open-label placebo vs double-blind placebo for irritable bowel syndrome: a randomized clinical trial

Pain, 2021
It is commonly believed that blinding to treatment assignment is necessary for placebos to have an effect. However, placebos administered without concealment (i.e., open-label placebos [OLP]) have recently been shown to be effective in some conditions ...
A. Lembo, J. Kelley, Judy W. Nee, Sarah Ballou, J. Iturrino, Vivian Cheng, V. Rangan, J. Katon, William Hirsch, I. Kirsch, Kathryn T. Hall, Roger B. Davis, T. Kaptchuk   +12 more
semanticscholar   +1 more source

A randomised, placebo-controlled study of RIPK1 inhibitor GSK2982772 in patients with active ulcerative colitis

BMJ Open Gastroenterology, 2021
Objective Tumour necrosis factor signalling via the receptor-interacting protein kinase 1 (RIPK1) pathway regulates colonic inflammation suggesting that RIPK1 inhibition may be a potential therapeutic target in ulcerative colitis (UC).
Nicola Scott, Kurt Brown, Paul Peter Tak, Kathy Weisel, Scott Berger, Susanne Wang, Marcy Powell, Matthijs Broer, Clarissa Watts, Debra J Tompson, Susan W Burriss, Simon Hawkins, Kathy Abbott-Banner   +12 more
doaj   +1 more source

Would You Take an Open-Label Placebo Pill or Give One to Your Child? Findings from a Cross-Sectional Survey. [PDF]

Psychol Res Behav Manag
Anne Schienle, Arved Seibel Department of Clinical Psychology, University of Graz, Graz, AustriaCorrespondence: Anne Schienle, Email anne.schienle@uni-graz.atBackground: Open-label placebos (OLPs), honestly prescribed regarding their inert nature, have ...
Schienle A, Seibel A.
europepmc   +2 more sources

No long-term effects after a 3-week open-label placebo treatment for chronic low back pain: a 3-year follow-up of a randomized controlled trial

Pain, 2022
Supplemental Digital Content is Available in the Text. A 3-year follow-up of 89 chronic back pain patients does not support the assumption that a 3-week open-label placebo treatment has long-term effects.
J. Kleine-Borgmann, Tim-Niklas Dietz, K. Schmidt, U. Bingel   +3 more
semanticscholar   +1 more source

'It's not my greengrocer, it's someone from the medical profession': A qualitative study regarding acceptability of deceptive and open-label placebo prescribing in France.

British Journal of Health Psychology, 2022
OBJECTIVES To explore participants' views regarding clinical use of deceptive placebo (DP) and open-label placebo (OLP) treatments. DESIGN Qualitative thematic analysis.
L. Druart, Oriana Vauthrin, N. Pinsault, C. Locher, C. Blease   +4 more
semanticscholar   +1 more source

Placebos in the era of open‐label trials: An update for clinicians [PDF]

European Journal of Clinical Investigation, 2018
AbstractPlacebos have been used extensively by vast numbers of physicians, in a majority of clinical trials. Placebo effects involve behavioural, psychological and genetic factors and have been subject to ethical controversies stemming from the use of deception in treating patients.
Iftach Sagy, Jonathan Abres, Ariel Winnick, Alan Jotkowitz   +3 more
openaire   +2 more sources

Associations Between Interindividual Differences, Expectations and Placebo and Nocebo Effects in Itch

Frontiers in Psychology, 2021
Introduction: Placebo and nocebo effects are positive and negative health outcomes that can be elicited by the psychosocial context. They can be mediated by expectations, and may emerge in somatic symptoms even when people are aware of these effects ...
Stefanie H. Meeuwis, Stefanie H. Meeuwis, Stefanie H. Meeuwis, Henriët van Middendorp, Henriët van Middendorp, Dieuwke S. Veldhuijzen, Dieuwke S. Veldhuijzen, Andrea W. M. Evers, Andrea W. M. Evers, Andrea W. M. Evers, Andrea W. M. Evers   +10 more
doaj   +1 more source

Conditioned open-label placebo for opioid reduction after spine surgery: a randomized controlled trial

Pain, 2021
Placebo effects have traditionally involved concealment or deception. However, recent evidence suggests that placebo effects can also be elicited when prescribed transparently as “open-label placebos” (OLPs), and that the pairing of an unconditioned ...
K. Flowers, Megan E. Patton, Valerie Hruschak, K. Fields, Emily Schwartz, J. Zeballos, James D. Kang, R. Edwards, T. Kaptchuk, Kristin L. Schreiber   +9 more
semanticscholar   +1 more source

Deceptive and non-deceptive placebos to reduce sadness: A five-armed experimental study

Journal of Affective Disorders Reports, 2022
Background: Placebo effects play an important role in psychopharmacological treatment of depression. Among the most potent mechanisms are positive treatment expectations. However, there is large heterogeneity in how they are induced.
Thilo Friehs, Winfried Rief, Julia A. Glombiewski, Julia Haas, Tobias Kube   +4 more
doaj   +1 more source

mere ownership of open-label placebo

, 2021
We try to replicate the findings of Yeung and colleagues (2019, 2020a, 2020b) using a non-deceptive open-label ...
Leo Fok, Victoria Yeung
core   +1 more source