Results 41 to 50 of about 92,747 (232)

A randomised, placebo-controlled study of RIPK1 inhibitor GSK2982772 in patients with active ulcerative colitis

BMJ Open Gastroenterology, 2021
Objective Tumour necrosis factor signalling via the receptor-interacting protein kinase 1 (RIPK1) pathway regulates colonic inflammation suggesting that RIPK1 inhibition may be a potential therapeutic target in ulcerative colitis (UC).
Nicola Scott, Kurt Brown, Paul Peter Tak, Kathy Weisel, Scott Berger, Susanne Wang, Marcy Powell, Matthijs Broer, Clarissa Watts, Debra J Tompson, Susan W Burriss, Simon Hawkins, Kathy Abbott-Banner   +12 more
doaj   +1 more source

Placebos in the era of open‐label trials: An update for clinicians [PDF]

European Journal of Clinical Investigation, 2018
AbstractPlacebos have been used extensively by vast numbers of physicians, in a majority of clinical trials. Placebo effects involve behavioural, psychological and genetic factors and have been subject to ethical controversies stemming from the use of deception in treating patients.
Iftach Sagy, Jonathan Abres, Ariel Winnick, Alan Jotkowitz   +3 more
openaire   +2 more sources

Associations Between Interindividual Differences, Expectations and Placebo and Nocebo Effects in Itch

Frontiers in Psychology, 2021
Introduction: Placebo and nocebo effects are positive and negative health outcomes that can be elicited by the psychosocial context. They can be mediated by expectations, and may emerge in somatic symptoms even when people are aware of these effects ...
Stefanie H. Meeuwis, Stefanie H. Meeuwis, Stefanie H. Meeuwis, Henriët van Middendorp, Henriët van Middendorp, Dieuwke S. Veldhuijzen, Dieuwke S. Veldhuijzen, Andrea W. M. Evers, Andrea W. M. Evers, Andrea W. M. Evers, Andrea W. M. Evers   +10 more
doaj   +1 more source

Deceptive and non-deceptive placebos to reduce sadness: A five-armed experimental study

Journal of Affective Disorders Reports, 2022
Background: Placebo effects play an important role in psychopharmacological treatment of depression. Among the most potent mechanisms are positive treatment expectations. However, there is large heterogeneity in how they are induced.
Thilo Friehs, Winfried Rief, Julia A. Glombiewski, Julia Haas, Tobias Kube   +4 more
doaj   +1 more source

Are open‐Label Placebos Ethical? Informed Consent and Ethical Equivocations [PDF]

Bioethics, 2016
AbstractThe doctor‐patient relationship is built on an implicit covenant of trust, yet it was not until the post‐World War Two era that respect for patient autonomy emerged as an article of mainstream medical ethics. Unlike their medical forebears, physicians today are expected to furnish patients with adequate information about diagnoses, prognoses ...
Charlotte, Blease, Luana, Colloca, Ted J, Kaptchuk   +2 more
openaire   +2 more sources

Open-label Placebos for Wound Healing: A Randomized Controlled Trial [PDF]

Annals of Behavioral Medicine, 2018
Open-label placebos are a novel treatment option, in which participants take placebos with full knowledge that they do not contain active medicine. Open-label placebo treatments have been shown to result in patient-reported symptom improvements, but they have not been tested on objectively measurable physiological outcomes such as wound healing.The ...
Ashwin, Mathur, Paul, Jarrett, Elizabeth, Broadbent, Keith J, Petrie   +3 more
openaire   +2 more sources

Placebos without deception: a randomized controlled trial in irritable bowel syndrome. [PDF]

PLoS ONE, 2010
Placebo treatment can significantly influence subjective symptoms. However, it is widely believed that response to placebo requires concealment or deception.
Ted J Kaptchuk, Elizabeth Friedlander, John M Kelley, M Norma Sanchez, Efi Kokkotou, Joyce P Singer, Magda Kowalczykowski, Franklin G Miller, Irving Kirsch, Anthony J Lembo   +9 more
doaj   +1 more source

Why psychotherapy is an open-label placebo and open-label placebos are psychotherapy

, 2023
Abstract In recent years, placebos have undergone a rapid development from methodological chaff to therapeutic wheat. Hereby, the role of placebos as a deceptive control in clinical trials, as well as negative denomination for anything murky, changed to an innovative promise, an effective as well as ethical treatment.
openaire   +1 more source

Motor- and cognition-related safety of pimavanserin in patients with Parkinson's disease psychosis

Frontiers in Neurology, 2022
BackgroundPimavanserin, a selective 5-HT2A inverse agonist/antagonist, is the only treatment approved by the US Food and Drug Administration for hallucinations and delusions associated with Parkinson's disease (PD) psychosis.AimWe aimed to evaluate motor-
Victor Abler, Cecilia Brain, Clive Ballard, Ana Berrio, Bruce Coate, Alberto J. Espay   +5 more
doaj   +1 more source

Imaginary pills and open-label placebos can reduce test anxiety by means of placebo mechanisms

Scientific Reports, 2023
AbstractPlacebos have been shown to be beneficial for various conditions even if administered with full transparency. Hence, so-called open-label placebos (OLPs) offer a new way to harness placebo effects ethically. To take this concept one step further, this study aimed at evaluating placebo effects without the use of a physical placebo, i.e., by ...
Buergler, Sarah, Sezer, Dilan, Bagge, Niels, Kirsch, Irving, Locher, Cosima, Carvalho, Claudia, Gaab, Jens   +6 more
openaire   +5 more sources