A comparison of open-label and deceptive placebo analgesia in a healthy sample [PDF]
Journal of Psychosomatic Research, 2021 A small number of studies have supported the efficacy of open-label placebos (OLPs) in reducing pain. However, research comparing the effectiveness of OLPs with deceptive placebos (DPs) is limited, and the relative impact on pain tolerance versus intensity are not yet understood.
Susanna Kola-Palmer, Chris Retzler
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Open-label placebos as adjunctive therapy for patients with depression
Contemporary Clinical Trials Communications, 2022 Background: Placebos prescribed as ‘regular’ medication can reduce symptoms of depression. However, using a placebo without patients' informed consent presents ethical issues.
Anne Schienle, Nina Jurinec
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"Let's see what happens:"-Women's experiences of open-label placebo treatment for menopausal hot flushes in a randomized controlled trial. [PDF]
PLoS ONE, 2022 Open-label (honestly prescribed) placebos are an ethical way to evoke placebo effects in patients. As part of a mixed-methods study, we conducted in-depth interviews with eight menopausal women who underwent and benefitted from open-label placebo ...
Yiqi Pan +3 more
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Open label placebo to treat fatigue in people with multiple sclerosis: feasibility and preliminary effects [PDF]
Pilot and Feasibility StudiesBackground Fatigue is highly prevalent in adults with multiple sclerosis (MS) and current treatments offer limited benefit. It has been speculated that placebos only have an effect when they are administered with deception and concealment, which is ...
Navneet Kaur Baidwan +8 more
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Patients’ experiences treated with open-label placebo versus double-blind placebo: a mixed methods qualitative study [PDF]
BMC Psychology, 2022 Background There is increasing evidence suggesting that open-label placebo (OLP) is an effective treatment for several medical conditions defined by self-report.
Julia W. Haas +9 more
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The role of positive information provision in open‐label placebo effects
Applied Psychology: Health and Well-Being, 2023 Abstract Open label placebos (OLPs) appear generally efficacious among clinical samples, but the empirical evidence regarding their use in non‐clinical and sub‐clinical samples, as well as when administered independent of a convincing rationale, is mixed. Healthy participants ( N
Kirsten Barnes, Kate Faasse
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Deceptive and open-label placebo effects in experimentally induced guilt: a randomized controlled trial in healthy subjects [PDF]
Scientific Reports, 2022 Placebos are known to yield significant effects in many conditions. We examined deceptive and open-label placebo effects on guilt, which is important for self-regulation and a symptom of mental disorders.
Dilan Sezer, Cosima Locher, Jens Gaab
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Can an Open-Label Placebo Be as Effective as a Deceptive Placebo? Methodological Considerations of a Study Protocol [PDF]
Medicines, 2020 Background: Placebo has been studied for many years and is ever-present in healthcare. In clinical practice, its use is limited by ethical issues raised by the deception entailed by its administration.
Leo Druart +6 more
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Open-Label Placebo Interventions With Drinking Water and Their Influence on Perceived Physical and Mental Well-Being [PDF]
Frontiers in Psychology, 2021 In recent years, the postulation that deception is necessary for placebos to have an effect on pain relief or increased well-being has come into question. Latest studies have shown that an openly administered mock drug works just as well as a deceptively
Marco Rathschlag +3 more
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Effects of Open- and Closed-Label Nocebo and Placebo Suggestions on Itch and Itch Expectations
Frontiers in Psychiatry, 2019 Placebo and nocebo effects have been shown to influence subjective symptoms such as itch. These effects can be induced by influencing outcome expectations through, for example, combining the application of an inert substance (e.g., a cream) with verbal ...
Stefanie H. Meeuwis +12 more
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