Results 21 to 30 of about 16,336,802 (316)
Open-label placebo treatment does not enhance cognitive abilities in healthy volunteers. [PDF]
Sci Rep, 2023 The use of so-called ‘smart drugs’ such as modafinil to improve cognitive performance has recently attracted considerable attention. However, their side effects have limited user enthusiasm. Open-label placebo (OLP) treatment, i.e., inert treatments that
Hartmann H +6 more
europepmc +2 more sources
JAMA Netw Open, 2023 Key Points Question Can conditioned open-label placebo (C-OLP) help increase the efficacy of treatment with methadone for opioid use disorder? Findings In this 2-group, single-blind randomized clinical trial including 131 individuals, 90-day retention in
Belcher AM +15 more
europepmc +2 more sources
Changes in neural processing and evaluation of negative facial expressions after administration of an open-label placebo. [PDF]
Sci Rep, 2022 A recent event-related potential (ERP) study found that an open-label placebo (OLP) reduced emotional distress during the viewing of unpleasant scenes and the amplitude of the late positive potential (LPP).
Schienle A, Unger I, Schwab D.
europepmc +2 more sources
Open-label placebos as adjunctive therapy for patients with depression
Contemporary Clinical Trials Communications, 2022 Background: Placebos prescribed as ‘regular’ medication can reduce symptoms of depression. However, using a placebo without patients' informed consent presents ethical issues.
Anne Schienle, Nina Jurinec
doaj +3 more sources
The impact of pharmaceutical form and simulated side effects in an open-label-placebo RCT for improving psychological distress in highly stressed students. [PDF]
Sci Rep, 2023 Open-label placebo (OLP) may be utilized to reduce psychological distress. Yet, potential contextual effects have not been explored. We investigated the impact of pharmaceutical form and the simulation of side effects in a parallel group RCT ...
Winkler A, Hahn A, Hermann C.
europepmc +2 more sources
The role of expectations and tailored feedback on the open-label Placebo effect. [PDF]
J Health PsycholOpen label placebos (OLPs) refer to the non-deceptive administration of inert treatment. This pre-registered study (AsPrediced#139837) explored the role of expectations and tailored health feedback on the OLP effect using an automated online procedure.
Barnes K, Faasse K.
europepmc +3 more sources
A comparison of open-label and deceptive placebo analgesia in a healthy sample [PDF]
Journal of Psychosomatic Research, 2021 A small number of studies have supported the efficacy of open-label placebos (OLPs) in reducing pain. However, research comparing the effectiveness of OLPs with deceptive placebos (DPs) is limited, and the relative impact on pain tolerance versus intensity are not yet understood.
Susanna Kola-Palmer, Chris Retzler
exaly +3 more sources
JAMA Pediatr, 2022 Importance Although it is widely believed that concealment or deception is required to elicit a placebo response, recent studies with adults suggest that open-label placebo (OLP) (ie, honestly prescribed placebos) can yield significant benefits.
Nurko S +11 more
europepmc +2 more sources
JAMA Netw OpenKey Points Question What are the clinical effects and brain mechanisms of open-label (honestly prescribed) placebos for chronic back pain? Findings In this randomized clinical trial of 101 adults with chronic back pain, an open-label subcutaneous placebo
Ashar YK +6 more
europepmc +2 more sources
Effects of Open- and Closed-Label Nocebo and Placebo Suggestions on Itch and Itch Expectations [PDF]
Frontiers in Psychiatry, 2019 Placebo and nocebo effects have been shown to influence subjective symptoms such as itch. These effects can be induced by influencing outcome expectations through, for example, combining the application of an inert substance (e.g., a cream) with verbal ...
Stefanie H. Meeuwis +12 more
doaj +2 more sources