Why do open-label placebos work? A randomized controlled trial of an open-label placebo induction with and without extended information about the placebo effect in allergic rhinitis. [PDF]
PLoS ONE, 2018 Several studies demonstrated that placebo treatment may have a significant impact on many different symptoms. While in the traditional view concealment of the placebo is essential, recent studies report intriguing evidence that placebos may work even ...
Michael Schaefer +2 more
doaj +6 more sources
Prescribing Placebos: An Experimental Examination of the Role of Dose, Expectancies, and Adherence in Open-Label Placebo Effects [PDF]
Annals of Behavioral Medicine, 2019 Recent evidence indicates that placebo effects can occur even when patients know that they are taking a placebo, termed the open-label placebo effect.To assess whether placebo dose (one pill per day vs. four pills per day), treatment expectancies, and adherence contribute to open-label placebo effects.Healthy undergraduate participants were randomly ...
Rob Horne, Kate Faasse, Jason El Brihi
exaly +8 more sources
Placebo Effects of Open-label Verbal Suggestions on Itch [PDF]
Acta Dermato-Venereologica, 2017 Placebo effects are positive outcomes that are not due to active treatment components, which may be elicited even when patients are aware of receiving an inert substance (open-label).
Stefanie H. Meeuwis +6 more
doaj +10 more sources
Evidencing general acceptability of open-label placebo use for tackling overtreatment in primary care: a mixed methods study [PDF]
BMC Medicine, 2023 Background Overtreatment poses a challenge to healthcare systems due to harmful consequences of avoidable side-effects and costs. This study presents the first account for examining the feasibility of placebo use for reducing overtreatment in primary ...
E. M. Krockow +4 more
doaj +4 more sources
The role of positive information provision in open‐label placebo effects
Applied Psychology: Health and Well-Being, 2023 Open label placebos (OLPs) appear generally efficacious among clinical samples, but the empirical evidence regarding their use in non-clinical and sub-clinical samples, as well as when administered independent of a convincing rationale, is mixed. Healthy
Kirsten Barnes, Kate Faasse
exaly +4 more sources
Do cognitive bias and heuristics influence improvement in knee pain in patients with knee osteoarthritis treated with open label placebo? The CHIPS study - An exploratory study using questionnaire and group concept mapping [PDF]
Osteoarthritis and Cartilage OpenObjective: This study explored if the patient-experience and the affect heuristic influenced improvements in painful symptoms, in response to open label placebo injections in patients with knee OA.
Tommy Kok Annfeldt +5 more
doaj +4 more sources
Open-Label Placebo Administration Decreases Pain in Elderly Patients With Symptomatic Knee Osteoarthritis – A Randomized Controlled Trial [PDF]
Frontiers in Psychiatry, 2022 BackgroundRecent studies indicate that the administration of open-label placebos (OLP) can improve symptoms in various medical conditions. The primary aim of this 3-week randomized controlled trial was to examine the effects of OLP treatments on pain ...
Elisabeth Olliges +8 more
doaj +4 more sources
Public and professional attitudes towards deceptive and open-label placebo in functional neurological disorder and wider neurological practice [PDF]
BMJ Neurology OpenBackground Placebo effects are powerful and have been suggested to be particularly relevant in certain neurological conditions, including functional neurological disorder (FND).Methods A survey on attitudes towards and current practice of deceptive ...
Mark J Edwards +2 more
doaj +3 more sources
Boosting open-label placebo effects in acute induced pain in healthy adults (BOLPAP-study): study protocol of a randomized controlled trial [PDF]
Frontiers in MedicineIntroductionPain is a highly prevalent symptom in the hospital setting, but treatment options remain limited. Harnessing the placebo effect in an ethical manner could provide a new possibility to reduce pain in clinical practice.
Matthijs de Leeuw +4 more
doaj +4 more sources
The roles of expectation, comparator, administration route, and population in open-label placebo effects: a network meta-analysis. [PDF]
Sci Rep, 2023 Three meta-analyses have demonstrated the clinical potential of open-label placebos (OLPs). However, there is a need to synthesize the existing evidence through more complex analyses that would make it possible to answer questions beyond mere efficacy ...
Buergler S, Sezer D, Gaab J, Locher C.
europepmc +2 more sources