Can the Open Label Placebo Rationale Be Optimized? [PDF]
Frontiers in Pain Research, 2021 Uwe Heiss +2 more
doaj +7 more sources
Do cognitive bias and heuristics influence improvement in knee pain in patients with knee osteoarthritis treated with open label placebo? The CHIPS study - An exploratory study using questionnaire and group concept mapping [PDF]
Osteoarthritis and Cartilage OpenObjective: This study explored if the patient-experience and the affect heuristic influenced improvements in painful symptoms, in response to open label placebo injections in patients with knee OA.
Tommy Kok Annfeldt +5 more
doaj +4 more sources
Open-Label Placebo Administration Decreases Pain in Elderly Patients With Symptomatic Knee Osteoarthritis – A Randomized Controlled Trial [PDF]
Frontiers in Psychiatry, 2022 BackgroundRecent studies indicate that the administration of open-label placebos (OLP) can improve symptoms in various medical conditions. The primary aim of this 3-week randomized controlled trial was to examine the effects of OLP treatments on pain ...
Elisabeth Olliges +8 more
doaj +4 more sources
Acta PsychologicaPositive and negative expectations crucially shape how we perceive our surroundings, including our emotional and cognitive abilities. Prior work shows that cognitive abilities in different domains can be modulated by placebo or nocebo effects, in ...
Jonas Potthoff, Helena Hartmann
doaj +5 more sources
Can observational learning reinforce open-label placebo hypoalgesia? [PDF]
Pain, 2023 Previous research has indicated that an open-label placebo can reduce pain in both healthy participants and chronic pain patients. As nondeceptive placebos seem to be an effective and more ethical alternative to deceptive placebos, optimizing this kind of treatment is essential.
Brączyk J, Bąbel P.
europepmc +4 more sources
Placebo Effects of Open-label Verbal Suggestions on Itch [PDF]
Acta Dermato-Venereologica, 2017 Placebo effects are positive outcomes that are not due to active treatment components, which may be elicited even when patients are aware of receiving an inert substance (open-label).
Stefanie H. Meeuwis +6 more
doaj +6 more sources
A randomized controlled trial of effects of open-label placebo compared to double-blind placebo and treatment-as-usual on symptoms of allergic rhinitis [PDF]
Scientific Reports, 2023 Placebo effects are known for numerous clinical symptoms. Until recently, deception of placebos was thought to be essential for placebo effects, but intriguing new studies suggest that even placebos without concealment (open-label placebos) may help ...
Michael Schaefer +2 more
doaj +2 more sources
Evidencing general acceptability of open-label placebo use for tackling overtreatment in primary care: a mixed methods study [PDF]
BMC Medicine, 2023 Background Overtreatment poses a challenge to healthcare systems due to harmful consequences of avoidable side-effects and costs. This study presents the first account for examining the feasibility of placebo use for reducing overtreatment in primary ...
E. M. Krockow +4 more
doaj +2 more sources
Neural underpinnings of open-label placebo effects in emotional distress. [PDF]
Neuropsychopharmacology, 2023 AbstractWhile placebo effects are well-known, research in the last decade revealed intriguing effects that placebos may have beneficial effects even when given without deception. At first glance, this seems paradoxical, but several studies have reported improvements in pain, depression, or anxiety.
Schaefer M +4 more
europepmc +3 more sources
The effect of open-label placebo on anxiety, cortisol, and pain levels in children with procedural pain [PDF]
Frontiers in PediatricsPurposeNeedle-related procedures are painful experiences for hospitalized children and are associated with anxiety, pain and stress. Open-label placebos (i.e., placebos administered honestly as an inert substance) have recently been shown to be as ...
Anna Lena Friedel +8 more
doaj +2 more sources