Effects of Open-Label Placebos on State Anxiety and Glucocorticoid Stress Responses [PDF]
Brain Sciences, 2021 Stress belongs to the most frequent negative feelings people are confronted with in daily life. Strategies against acute stress include, e.g., relaxation techniques or medications, but it is also known that placebos can successfully reduce negative ...
Michael Schaefer +2 more
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Open-label placebos reduce weight in obesity: a randomized controlled trial [PDF]
Scientific ReportsObesity is a major public health problem worldwide. Different approaches are known to face this problem, for example, dieting, surgery, or drug interventions. It has also been shown that placebos may help to reduce weight and hunger feelings, but the use
Michael Schaefer +2 more
doaj +6 more sources
Open-label placebos as adjunctive therapy for patients with depression [PDF]
Contemporary Clinical Trials Communications, 2022 Background: Placebos prescribed as ‘regular’ medication can reduce symptoms of depression. However, using a placebo without patients' informed consent presents ethical issues.
Anne Schienle, Nina Jurinec
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Effects of open-label placebos in clinical trials: a systematic review and meta-analysis [PDF]
Scientific Reports, 2021 Open-label placebos (OLPs) are placebos without deception in the sense that patients know that they are receiving a placebo. The objective of our study is to systematically review and analyze the effect of OLPs in comparison to no treatment in clinical ...
Stefan Schmidt
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Imaginary pills and open-label placebos can reduce test anxiety by means of placebo mechanisms [PDF]
Scientific Reports, 2023 Placebos have been shown to be beneficial for various conditions even if administered with full transparency. Hence, so-called open-label placebos (OLPs) offer a new way to harness placebo effects ethically.
Sarah Buergler +6 more
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Open-label Placebos for Wound Healing: A Randomized Controlled Trial [PDF]
Annals of Behavioral Medicine, 2018 Open-label placebos are a novel treatment option, in which participants take placebos with full knowledge that they do not contain active medicine. Open-label placebo treatments have been shown to result in patient-reported symptom improvements, but they have not been tested on objectively measurable physiological outcomes such as wound healing.The ...
Paul Jarrett +2 more
exaly +5 more sources
Why do open-label placebos work? A randomized controlled trial of an open-label placebo induction with and without extended information about the placebo effect in allergic rhinitis. [PDF]
PLoS ONE, 2018 Several studies demonstrated that placebo treatment may have a significant impact on many different symptoms. While in the traditional view concealment of the placebo is essential, recent studies report intriguing evidence that placebos may work even ...
Michael Schaefer +2 more
doaj +6 more sources
Deceptive and open-label placebo effects in experimentally induced guilt: a randomized controlled trial in healthy subjects [PDF]
Scientific Reports, 2022 Placebos are known to yield significant effects in many conditions. We examined deceptive and open-label placebo effects on guilt, which is important for self-regulation and a symptom of mental disorders.
Dilan Sezer, Cosima Locher, Jens Gaab
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Roles of administration route, expectation, and belief in placebos in a randomized controlled trial with open-label placebos [PDF]
Scientific ReportsRecent reports challenge the view that placebos need to be given in deception. Numerous studies report remarkable effects when giving placebos honestly in an open way. However, the mechanisms of open-label placebos still remain to be cleared. For example,
Michael Schaefer +2 more
doaj +4 more sources
Can open label placebos improve pain and gluten tolerance via open label placebos in fibromyalgia patients? A study protocol for a randomised clinical trial in an outpatient centre [PDF]
BMJ Open, 2023 Introduction Fibromyalgia syndrome (FMS) is defined as a medical condition with chronic widespread musculoskeletal pain accompanied by mood disorders, fatigue and sleep disturbances. Treatment of this condition can often be challenging.
Margitta Worm +3 more
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