Effects of open-label placebos in clinical trials: a systematic review and meta-analysis [PDF]
Scientific Reports, 2021 Open-label placebos (OLPs) are placebos without deception in the sense that patients know that they are receiving a placebo. The objective of our study is to systematically review and analyze the effect of OLPs in comparison to no treatment in clinical ...
Stefan Schmidt
exaly +6 more sources
Effects of Open-Label Placebos on State Anxiety and Glucocorticoid Stress Responses [PDF]
Brain Sciences, 2021 Stress belongs to the most frequent negative feelings people are confronted with in daily life. Strategies against acute stress include, e.g., relaxation techniques or medications, but it is also known that placebos can successfully reduce negative ...
Michael Schaefer +2 more
doaj +8 more sources
Open-label placebos as adjunctive therapy for patients with depression [PDF]
Contemporary Clinical Trials Communications, 2022 Background: Placebos prescribed as ‘regular’ medication can reduce symptoms of depression. However, using a placebo without patients' informed consent presents ethical issues.
Anne Schienle, Nina Jurinec
doaj +5 more sources
Why do open-label placebos work? A randomized controlled trial of an open-label placebo induction with and without extended information about the placebo effect in allergic rhinitis. [PDF]
PLoS ONE, 2018 Several studies demonstrated that placebo treatment may have a significant impact on many different symptoms. While in the traditional view concealment of the placebo is essential, recent studies report intriguing evidence that placebos may work even ...
Michael Schaefer +2 more
doaj +7 more sources
Open-label placebos reduce weight in obesity: a randomized controlled trial [PDF]
Scientific ReportsObesity is a major public health problem worldwide. Different approaches are known to face this problem, for example, dieting, surgery, or drug interventions. It has also been shown that placebos may help to reduce weight and hunger feelings, but the use
Michael Schaefer +2 more
doaj +5 more sources
Imaginary pills and open-label placebos can reduce test anxiety by means of placebo mechanisms [PDF]
Scientific Reports, 2023 Placebos have been shown to be beneficial for various conditions even if administered with full transparency. Hence, so-called open-label placebos (OLPs) offer a new way to harness placebo effects ethically.
Sarah Buergler +6 more
doaj +7 more sources
Providing open-label placebos remotely-A randomized controlled trial in allergic rhinitis. [PDF]
PLoS ONE, 2021 BackgroundPlacebos can reduce physical symptoms even when provided with full honesty and disclosure. Yet, the precise mechanisms underlying the effects of "open-label placebos" (OLPs) have remained subject of debate.
Tobias Kube +3 more
doaj +7 more sources
Open-label placebos for menopausal hot flushes: a randomized controlled trial. [PDF]
Sci Rep, 2020 This study investigated the efficacy of an open-label placebo (OLP) treatment for menopausal hot flushes. Women with at least five moderate or severe hot flushes per day were allocated to receive four weeks of OLP for twice a day or no-treatment ...
Pan Y +5 more
europepmc +7 more sources
Are open‐Label Placebos Ethical? Informed Consent and Ethical Equivocations [PDF]
Bioethics, 2016 AbstractThe doctor‐patient relationship is built on an implicit covenant of trust, yet it was not until the post‐World War Two era that respect for patient autonomy emerged as an article of mainstream medical ethics. Unlike their medical forebears, physicians today are expected to furnish patients with adequate information about diagnoses, prognoses ...
Charlotte R Blease, Luana Colloca
exaly +7 more sources
Effects of open-label placebos on test performance and psychological well-being in healthy medical students: a randomized controlled trial [PDF]
Scientific Reports, 2021 Psychological distress is prevalent in students and can predispose to psychiatric disorders. Recent findings indicate that distress might be linked to impaired cognitive performance in students.
Julian Kleine-Borgmann
exaly +4 more sources