Results 61 to 70 of about 53,666 (300)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Study of the Acoustic Suitability of an Open Plan Office Based on STI and DL2 Simulations
Archives of Acoustics, 2013 Many business offices around the world are organized as open plan offices. Therefore, studies about the acoustic comfort of the people who work in them have become increasingly important.
Carolina Reich Marcon PASSERO +1 more
doaj
Buildings, 2018 Open-plan offices have lower construction costs, allowing for significant savings in space and, according to designers, facilitate communication between workers, thus, improving collaboration, as well as the exchange of ideas.
Gino Iannace +2 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Designs for Open-Plan and Conventional Offices [PDF]
The Journal of the Acoustical Society of America, 1970 Interior design views concerning open-plan and conventional offices will be presented. Planning concepts, function, appearance, materials, and costs will be discussed and contrasted for various office types. Experiences with clients' reactions to various office environments will be reviewed.
openaire +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Acoustic design of open-plan offices
, 2010 The acoustic conditions in open-plan offices were investigated in a Nordic cooperation project. Measurements were carried out in five open-plan offices along with a questionnaire to gather the staff’s subjective judgments.A programme for the acoustic ...
Nilsson, Erling, Hellström, Björn,
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