Results 101 to 110 of about 1,136,084 (297)
Advanced Sustainable Systems, EarlyView.Nanosafety data provide a guiding example for establishing best practices in data management, aligning with FAIR principles and quality criteria. This review explores existing quality assessment approaches for reliability, relevance, and completeness, emphasizing the need for harmonization and adaptation to nanomaterials and advanced materials. The aim
Verónica I. Dumit +43 more
wiley +1 more source
Visions and Challenges in Managing and Preserving Data to Measure Quality of Life
, 2018 Health-related data analysis plays an important role in self-knowledge, disease prevention, diagnosis, and quality of life assessment. With the advent of data-driven solutions, a myriad of apps and Internet of Things (IoT) devices (wearables, home ...
Estrada-Galinanes, Vero, Wac, Katarzyna
core +1 more source
Advanced Science, EarlyView.Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann +26 more
wiley +1 more source
Consumed by Abdominal Distention
Arthritis Care &Research, Accepted Article.
Abimbola Fadairo‐Azinge +3 more
wiley +1 more source
Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS
Advanced Science, EarlyView.This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu +14 more
wiley +1 more source
THE MIND AND BRAIN SCHOLAR AS A HITCH-HIKER IN POST-GUTENBERG GALAXY: PUBLISHING AT 2000 AND BEYOND
, 2000 Electronic journal (e-journal) publishing has started to change the ways we think about publish-ing. However, many scholars and scientists in the mind and brain sciences are still ignorant of the new possibilities and on-going debates.
Corre, Marianne +2 more
core
Advanced Science, EarlyView.Single‐cell transcriptomic and functional analyses identify SEMA3C as a key regulator of tumor progression and tumor microenvironment remodeling in penile squamous cell carcinoma. SEMA3C promotes epithelial–mesenchymal transition, tumor growth, and invasion while shaping an immunosuppressive microenvironment, highlighting its potential as a prognostic ...
Xiheng Hu +21 more
wiley +1 more source
The Open Challenge: A Brief History [PDF]
, 2010 Milestones in the history of the Open Access (OA) Movement, especially the 1994 "Subversive Proposal" for authors to self-archive their peer-reviewed journal articles, the creation of the first OAI-compliant open source software for creating an ...
Harnad, Stevan
core
PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC
Advanced Science, EarlyView.CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao +16 more
wiley +1 more source
Advanced Science, EarlyView.CellPolaris decodes how transcription factors guide cell fate by building gene regulatory networks from transcriptomic data using transfer learning. It generates tissue‐ and cell‐type‐specific networks, identifies master regulators in cell state transitions, and simulates TF perturbations in developmental processes.
Guihai Feng +27 more
wiley +1 more source