Results 141 to 150 of about 1,249,788 (300)
, 2002 Das Open Archives Forum ist eine begleitende Maßnahme der Information Society Technologies (IST) Programme der Europäischen Union. OA-Forum unterstützt vor allem EU-Projekte, nationale Initiativen sowie andere Gruppen, die einen Open Archive Ansatz für den Aufbau von Schnittstellen zwischen verteilten Archiven nutzen. Ein Hauptgewicht liegt hierbei auf
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Advanced Science, EarlyView.Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu +11 more
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Advanced Science, EarlyView.Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang +12 more
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Opportunities and Challenges of establishing Open Access Repositories: A case study of OpenMED@NIC [PDF]
, 2008 National Informatics Centre had established a subject repository in May 2005. It is meant for Medical and Allied Sciences and named as OpenMED@NIC http://openmed.nic.in.
Singh, Sukhdev +2 more
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Advanced Science, EarlyView.This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li +15 more
wiley +1 more source
, 2017 Archive of the Storify story previously found at https://storify.com/jillasella/open-access-outreach-chat. It documents a Twitter conversation between @jillasella and @OpenAccessHulk (and a few others) about challenges and best practices for librarians ...
Open Access Hulk,, Cirasella, Jill
core
UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation
Advanced Science, EarlyView.ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro +7 more
wiley +1 more source
Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer
Advanced Science, EarlyView.Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen +13 more
wiley +1 more source
, 2005 Geophysics Open archive. Free access to worldwide scientists during search and submission process. Earth-Prints is an open archive created and maintained by Istituto Nazionale di Geofisica e Vulcanologia with the collaboration of Programma Nazionale ...
Chiodetti, A. G.
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, 2019 Criação da Base de Dados com acesso aberto do Projeto ...
Matildes, Rita +6 more
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