Results 181 to 190 of about 26,317,005 (275)

Loss of Lepr in Fibroblasts Drives Tumor Development by Promoting Macrophage Infiltration

Advanced Science, EarlyView.
TNFα and TGFβ signaling reprograms Lepr+ fibroblasts toward a LeprnegMmphigh inflammatory CAF (iCAF) state, with downregulation of the Tcf21‐Lepr axis contributing to this transition. Lepr loss induces Csf3, which contributes to the enhanced macrophage‐recruiting capacity of these iCAFs, thereby promoting tumor development. Thus, inflammatory signaling
Manyu Song, Wuqi Yang, Bangran Qi, Liyuan Hou, Xu Yang, Jiuzhi Xu, Shengyuan Tian, Shuiling Jin, Lu Yu, Zhengquan Yu, Min Deng, Jiaqiang Huang, Suoqin Jin, Cong Lv   +13 more
wiley   +1 more source

Radiomics meets pathology: Building the bridge for precision oncology. [PDF]

Cytojournal
Patanè V, Brunese MC, Marinelli L, Martinelli E, Nardone V, Franco R, Cappabianca S, Reginelli A.   +7 more
europepmc   +1 more source

Single‐Cell Insights Into Pathogenic Profile of Orchitis and SREBP2‐Associated Cholesterol Dysregulation in Spermatogenic Failure

Advanced Science, EarlyView.
A first single‐cell atlas of human orchitis reveals coordinated germ‐cell loss, somatic niche dysfunction, and immune‐metabolic remodeling. Aberrant SREBP2 activation in testicular somatic cells emerges as a central pathogenic node, while Fatostatin‐mediated inhibition of the SREBP pathway improves spermatogenesis, fibrosis, and lipid accumulation in a
Yanlin Tang, Qiaoling Jiang, Yuwen Liu, Wenxiu Zhang, Lina Cui, Xiaojian Lu, Ziyan Zhuang, Jianxing Cheng, Songzhan Gao, Yangyi Fang, Kai Hong, Jie Qiao, Xiaoyan Wang, Hui Jiang, Zhe Zhang, Jingtao Guo, Qiang Liu   +16 more
wiley   +1 more source

Southern Ocean regime shift: divergent trends in surface phytoplankton community composition using a diagnostic pigment framework. [PDF]

Nat Commun
Adroli N, Hayward A, Strutton P, Ellwood M.   +3 more
europepmc   +1 more source

Early‐Life Polyethylene Microplastic Exposure Exacerbates ADHD‐Like Behaviors in Mice via PI3K/AKT1/Nrf2 Signaling: Evidence From the Pilot Cohort and Multi‐Omics Analyses

Advanced Science, EarlyView.
Circulating polyethylene microplastic burden is positively associated with heightened ADHD symptom severity and systemic redox‐inflammatory imbalance in children. Mechanistic investigation in a developmental co‐exposure mouse model further demonstrates that microplastics aggravate ADHD‐like behaviors, dopaminergic dysregulation, and oxidative ...
Yufan Luo, Ruijin Xie, Hua Xu, Xue Xiao, Wei Xiao, Qiyang Pan, Shengjie Xu, Li Liu, Zeliang Xiao, Yue Zhou, Chenyu Sun, Yu Wu, Yueying Liu   +12 more
wiley   +1 more source

Detecting poliovirus sequences in the sequence read archive database using bioinformatics tools. [PDF]

Front Bioinform
Farrell K, Tang K, Mashiku M, Abay D, Longo J, Ramos E, Leventhal-Douglas G, Rohrbaugh M, Chenoweth P, Burns CC, Zhao K.   +10 more
europepmc   +1 more source

The wizards of Oz : open archives initiatives down under

, 2004
The structure of presentation is to adopt wide generic background of OAI, not to get into details such as current debate on precise definition of Open Access, to provide brief overview of background and current state of play in Australia and to cover E-Prints/ E-Presses and digital repository movements in universities and National Library of Australia.
openaire   +1 more source

A Large Scale Multi‐Modal Workflow for Battery Characterization: From Concept to Implementation

Advanced Energy Materials, EarlyView.
Isolated characterization techniques produce independent datasets and single‐property insights. However, progressively more holistic interpretations of battery‐material behavior is needed in the future. Here we demonstrate a coordinated multimodal workflow enabling the correlation of heterogeneous datasets and the construction of multidimensional ...
François Cadiou, Cinthya Herrera, Duncan Atkins, Elixabete Ayerbe, Giorgio Baraldi, Stéphanie Belin, Anass Benayad, Didier Blanchard, Federico Capone, Ennio Capria, Isidora Cekic‐Laskovic, Robert Dominko, Kristina Edström, Ajay Gautam, Lukas Helfen, Antonella Iadecola, Quentin Jacquet, Gregor Kapun, Xinyu Li, Aleksandar Matic, Nataliia Mozhzhukhina, Andrew J. Naylor, Poul Norby, Chris O'Keefe, Alexandre Ponrouch, Jean‐Pascal Rueff, Elena Tchernykova, Deyana Tchitchekova, Israel Temprano, Nikita Vostrov, Marnix Wagemaker, Martin Winter, Christian Wölke, Tejs Vegge, Sandrine Lyonnard   +34 more
wiley   +1 more source

Charting confidence in white matter brain charts: enabling study planning through stability validation. [PDF]

J Med Imaging (Bellingham)
Kim ME, Rudravaram G, Saunders AM, Gao C, Ramadass K, Newlin NR, Kanakaraj P, Bogdanov S, Jefferson AL, Morgan VL, Roche A, Englot DJ, Resnick SM, Held LLB, Bilgel M, Cutting LE, Barquero LA, D'Archangel MA, Nguyen TQ, Humphreys KL, Niu Y, Vinci-Booher S, Cascio CJ, Pechman KR, Shashikumar N, Team THS, Neuroimaging Initiative AD, Team TBS, Li Z, Zhang P, Gore JC, Liu Y, Zuo L, Huo Y, Archer DB, Hohman TJ, Davis LT, Schilling KG, Moyer DC, Landman BA.   +39 more
europepmc   +1 more source

Poster : SODHA. Social Sciences and Digital Humanities Archive

This poster presents the mission, services, and ongoing developments of SODHA.be (Social Sciences and Digital Humanities Archive), the Belgian long‑term data archive for SSH research.
Van der Eycken, Johan
core