Results 131 to 140 of about 306,323 (300)
Advanced Science, EarlyView.This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi +10 more
wiley +1 more source
Desafios à comunidade ibero-americana de metadados em repositórios digitais para maximização da interoperabilidade [PDF]
, 2017 [Excerto] Introdução: Acesso Aberto (AA) significa “acesso em linha permanente, imediato e gratuito ao texto integral de artigos de investigação por qualquer pessoa em qualquer ponto da web (HARNAD, 2007).
Baptista, Ana Alice
core
Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1
Advanced Science, EarlyView.Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang +10 more
wiley +1 more source
Sharing Social Research Data in Ireland: A Practical Tool [PDF]
, 2016 Your data is valuable and has an importance outside your own original project. Allowing other researchers to reuse your data maximises the impact of your work, and benefits both the scholarly community and society in general.
Brid McGrath, Robin Hanan
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Physical Origin of Temperature Induced Activation Energy Switching in Electrically Conductive Cement
Advanced Science, EarlyView.The temperature‐induced Arrhenius activation energy switching phenomenon of electrical conduction in electrically conductive cement originates from structural degradation within the biphasic ionic‐electronic conduction architecture and shows percolation‐governed characteristics: pore network opening dominates the low‐percolation regime with downward ...
Jiacheng Zhang +7 more
wiley +1 more source
Advanced Science, EarlyView.Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang +12 more
wiley +1 more source
Advanced Science, EarlyView.We generated multi‐tissue single‐cell transcriptomic atlases of camels and cattle, uncovering conserved and lineage‐specific cellular features across digestive and metabolic systems. Cross‐species comparisons revealed the evolutionary origin of the camel glandular sac and identified novel cell populations linked to physiological specialization ...
Tao Shi +22 more
wiley +1 more source
Open Knowledge Resources for Higher Education: Scholarly Publications, Course Materials, Academic Software [PDF]
, 2006 This paper will explain why electronic knowledge resources in academia cannot only be regarded as private commodities, but also as public goods. After sketching a concept of public goods for a postnational, global society, three types of electronic ...
Thomas Pfeffer
core
Open Archives Initiative protocol development and implementation at arXiv
, 2001 15 pages. Expanded version of talk presented at Open Archives Initiative Open Meeting in Washington, DC, USA on 23 January ...
openaire +2 more sources
Advanced Science, EarlyView.Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma +10 more
wiley +1 more source