A pentasymmetric open channel blocker for Cys-loop receptor channels. [PDF]
PLoS One, 2014 γ-Aminobutyric acid type A receptors (GABAA receptors) are chloride ion channels composed of five subunits, mediating fast synaptic and tonic inhibition in the mammalian brain.
Carta V +6 more
europepmc +3 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Development and technical and economic comparison of design decisions for prevention the entry of the superficial and ground waters to the territory of the Metallurgical terminal of port Ust-Luga (rus) [PDF]
Инженерно-строительный журнал, 2011 The problem of the paper is drawing up of the project on protection the territory of the Metallurgical terminal of port Ust’-Luga from flooding by the superficial and ground waters.
Oleshko V.A. +3 more
doaj
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Numerical simulation of flow over a rough bed [PDF]
, 2007 This paper presents results of a direct numerical simulation (DNS) of turbulent flow over the rough bed of an open channel. We consider a hexagonal arrangement of spheres on the channel bed.
Williams, J.J.R. +2 more
core +1 more source
Experimental Investigation on the Performance Analysis of a Constructed Hydro-Powered Coil Pump
Engineering TransactionsA hydro-powered water pumping system is one of the most important systems for upland areas in terms of supplying water for irrigation and daily usage.
Md. Alamgir HOSSAIN +2 more
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
“Isolated–roughness in open channel flows” [PDF]
, 2010 Obiettivo della ricerca è ridurre l’energia cinetica di una corrente ipercritica inserendo in alveo elementi dissipativi di varia forma, ma geometricamente definiti.
LEOPARDI, Maurizio
core
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Performance of an Echo Canceller and Channel Estimator for On-Channel Repeaters in DVB-T/H Networks [PDF]
, 2007 This paper investigates the design and performance of an FIR echo canceller for on-channel repeaters in DVB-T/H network within the framework of the PLUTO project. The possible approaches for echo cancellation are briefly reviewed and the main guidelines
Cosmas, John P. +11 more
core +1 more source