Results 111 to 120 of about 284,682 (289)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Dynamic reorganization of open chromatin underlies diverse transcriptomes during spermatogenesis [PDF]

, 2017
During spermatogenesis, germ cells undergo massive cellular reconstruction and dynamic chromatin remodeling to facilitate highly diverse transcriptomes, which are required for the production of functional sperm.
Barski, Artem, So Maezawa, Maezawa, So, Masashi Yukawa, Satoshi H Namekawa, Namekawa, Satoshi H, Alavattam, Kris G, Artem Barski, Yukawa, Masashi, Kris G Alavattam   +9 more
core   +1 more source

Leo1 is essential for the dynamic regulation of heterochromatin and gene expression during cellular quiescence

Epigenetics & Chromatin, 2019
Background Cellular quiescence is a reversible differentiation state during which cells modify their gene expression program to inhibit metabolic functions and adapt to a new cellular environment. The epigenetic changes accompanying these alterations are
Eriko Oya, Mickaël Durand-Dubief, Adiel Cohen, Vladimir Maksimov, Catherine Schurra, Jun-ichi Nakayama, Ronit Weisman, Benoit Arcangioli, Karl Ekwall   +8 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Nucleic acids and chromatin

, 2010
This unit helps you understand the properties of nucleotides and how they contribute to secondary and tertiary structures of nucleic acids at the molecular level.
Open University
core  

Interaction of HP1 and Brg1/Brm with the Globular Domain of Histone H3 Is Required for HP1-Mediated Repression [PDF]

, 2009
The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. These proteins contain two related domains known as the chromo- and the chromoshadow-domain.
Fan Hua-Ying, Kingston Robert E., Violaine Saint-André, Christian Muchardt, Saint-Andre, Violaine, Imhof Axel, Batsché Eric, Jang Suk Min, Kingston, Robert E., Saliha Azebi, Robert E Kingston, Axel Imhof, Jang, Suk Min, Eskeland, Ragnhild, Eskeland Ragnhild, Muchardt Christian, Eric Batsché, Azebi Saliha, Fan, Hua-Ying, Muchardt, Christian, Batsche, Eric, Hua-Ying Fan, Marc Lavigne, Ragnhild Eskeland, Saint-André Violaine, Imhof, Axel, Lavigne, Marc, Azebi, Saliha, Suk Min Jang, Lavigne Marc   +29 more
core   +1 more source

Dosage compensation and sex-specific epigenetic landscape of the X chromosome in the pea aphid

Epigenetics & Chromatin, 2017
Background Heterogametic species display a differential number of sex chromosomes resulting in imbalanced transcription levels for these chromosomes between males and females.
Gautier Richard, Fabrice Legeai, Nathalie Prunier-Leterme, Anthony Bretaudeau, Denis Tagu, Julie Jaquiéry, Gaël Le Trionnaire   +6 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The TFAP2C-Regulated OCT4 Naive Enhancer Is Involved in Human Germline Formation

Cell Reports, 2018
Summary: Human primordial germ cells (hPGCs) are the first embryonic progenitors in the germ cell lineage, yet the molecular mechanisms required for hPGC formation are not well characterized.
Di Chen, Wanlu Liu, Jill Zimmerman, William A. Pastor, Rachel Kim, Linzi Hosohama, Jamie Ho, Marianna Aslanyan, Joanna J. Gell, Steven E. Jacobsen, Amander T. Clark   +10 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source