Results 121 to 130 of about 408,119 (206)

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

PAIR: Reconstructing Single-Cell Open-Chromatin Landscapes for Transcription Factor Regulome Mapping. [PDF]

Adv Sci (Weinh)
Su Y, Qi Q, Fan Y, Wang Y, Hao G, Wong KC, Wang Y, Li X.   +7 more
europepmc   +1 more source

RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops

Advanced Science, EarlyView.
This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang, Yupo Wu, Jiachang Hou, Lixia Gao, Longqi Pan, Cuicui Shen, Chuanji Zhao, Feng Gao, Yi Zhang, Li Ren, Xiaoping Fang, Xiaoling Dun, Shengyi Liu, Lijiang Liu   +13 more
wiley   +1 more source

COCA-seq: genome-wide mapping of O-GlcNAc-associated open chromatin. [PDF]

Acta Biochim Biophys Sin (Shanghai)
Ge C, Zhao R, Jiang H, Chen Q, Yu Z, Yang H, Jiang X, Ma Q, Han L, Yu K, Li G, Huang H, Wang W, Liu Y, Zhang Q, Jin X.   +15 more
europepmc   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Single-cell resolution of an open chromatin signature in persister tumor cells. [PDF]

Cell Rep
Dumbrava MG, Mohammed Ismail W, Sandoval L, Mazzone A, Aalam SMM, Ritting ML, Hou X, Xie Y, Hamernick S, Hu C, Couch FJ, Harrington SP, Kaufmann SH, Kannan N, Weroha SJ, Gaspar-Maia A.   +15 more
europepmc   +1 more source

NicE-C efficiently reveals open chromatin-associated chromosome interactions at high resolution. [PDF]

Genome Res, 2022
Luo Z, Zhang R, Hu T, Zhu Y, Wu Y, Li W, Zhang Z, Yao X, Liang H, Song X.   +9 more
europepmc   +1 more source

Overcoming Artificial Structures in Resolution‐Enhanced Hi‐C Data by Signal Decomposition and Multi‐Scale Attention

Advanced Science, EarlyView.
Deep‐learning‐based signal enhancement is an effective way to recover high‐resolution details from a low‐resolution chromatin contact map. However, due to computational challenges, existing methods commonly divide up the contact map into small patches and create artificial discontinuities at patch boundaries.
Qinyao Li, Kelly Yichen Li, Chiara Nicoletti, Stephen Kwok‐Wing Tsui, Pier Lorenzo Puri, Qin Cao, Kevin Y. Yip   +6 more
wiley   +1 more source

Persistent open chromatin state in early-life stress-activated cells of the VTA. [PDF]

Sci Rep
Rashford RL, DeBerardine M, Dan S, Bennett SN, Peña CJ.   +4 more
europepmc   +1 more source

Genome-wide chromatin accessibility analysis unveils open chromatin convergent evolution during polyploidization in cotton. [PDF]

Proc Natl Acad Sci U S A, 2022
Han J, Lopez-Arredondo D, Yu G, Wang Y, Wang B, Wall SB, Zhang X, Fang H, Barragán-Rosillo AC, Pan X, Jiang Y, Chen J, Zhang H, Zhou BL, Herrera-Estrella L, Zhang B, Wang K.   +16 more
europepmc   +1 more source