Results 201 to 210 of about 284,682 (289)

mop1 affects maize recombination landscapes by modulating methylation of MITEs near genes in open chromatin. [PDF]

Nat Commun
Hasan MM, Yin L, Wang M, Pawlowski WP, Zhao M.   +4 more
europepmc   +1 more source

Matching queried single-cell open-chromatin profiles to large pools of single-cell transcriptomes and epigenomes for reference supported analysis. [PDF]

Genome Res, 2023
Mishra S, Pandey N, Chawla S, Sharma M, Chandra O, Jha IP, SenGupta D, Natarajan KN, Kumar V.   +8 more
europepmc   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

ISDH-seq: a robust methodology for profiling and characterization of open chromatin. [PDF]

Plant Biotechnol J
Li Z, Run Y, Yang Y, Shi Y, Tavakoli M, Peng Y, She L, Borovskii G, Zhang W.   +8 more
europepmc   +1 more source

Expanded Potential Stem Cells from Human Embryos Have an Open Chromatin Configuration with Enhanced Trophoblast Differentiation Ability. [PDF]

Adv Sci (Weinh), 2023
Chen ACH, Lee YL, Ruan H, Huang W, Fong SW, Tian S, Lee KC, Wu GM, Tan Y, Wong TCH, Wu J, Zhang W, Cao D, Chow JFC, Liu P, Yeung WSB.   +15 more
europepmc   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

Open chromatin-guided interpretable machine learning reveals cancer-specific chromatin features in cell-free DNA. [PDF]

Commun Biol
Gunarathna SD, Nagornyuk A, Belabbaci NA, Nguyen R, Ghosh B, Ganai S, Lemke T, Garry C, Saotome M, Yu M, Takada M, Wang X, Takaku M.   +12 more
europepmc   +1 more source

Harnessing changes in open chromatin determined by ATAC-seq to generate insulin-responsive reporter constructs. [PDF]

BMC Genomics, 2022
Merrill CB, Montgomery AB, Pabon MA, Shabalin AA, Rodan AR, Rothenfluh A.   +5 more
europepmc   +1 more source

3D Chromatin Architecture Provides Insights Into Leaf Trait Variation Among Pear Species

Advanced Science, EarlyView.
ABSTRACT Three‐dimensional (3D) chromatin architecture plays a fundamental role in eukaryotic gene regulations, its functional significance in perennial fruit trees remains poorly characterized despite extensive applications in crop genomics. Here, we developed high‐resolution (∼5 kb) Hi‐C maps of Pyrus and compared 3D genomic architecture of three ...
Yueyuan Liu, Chenhui Han, Cheng Xue, Manyi Sun, Bobo Song, Yongsong Xue, Guangyan Yang, Shaozhuo Xu, Wei Wei, Jiaming Li, Runze Wang, Jun Wu   +11 more
wiley   +1 more source

Inferring mammalian tissue-specific regulatory conservation by predicting tissue-specific differences in open chromatin. [PDF]

BMC Genomics, 2022
Kaplow IM, Schäffer DE, Wirthlin ME, Lawler AJ, Brown AR, Kleyman M, Pfenning AR.   +6 more
europepmc   +1 more source