Results 191 to 200 of about 284,682 (289)

Single-cell resolution of an open chromatin signature in persister tumor cells. [PDF]

Cell Rep
Dumbrava MG, Mohammed Ismail W, Sandoval L, Mazzone A, Aalam SMM, Ritting ML, Hou X, Xie Y, Hamernick S, Hu C, Couch FJ, Harrington SP, Kaufmann SH, Kannan N, Weroha SJ, Gaspar-Maia A.   +15 more
europepmc   +1 more source

NicE-C efficiently reveals open chromatin-associated chromosome interactions at high resolution. [PDF]

Genome Res, 2022
Luo Z, Zhang R, Hu T, Zhu Y, Wu Y, Li W, Zhang Z, Yao X, Liang H, Song X.   +9 more
europepmc   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Persistent open chromatin state in early-life stress-activated cells of the VTA. [PDF]

Sci Rep
Rashford RL, DeBerardine M, Dan S, Bennett SN, Peña CJ.   +4 more
europepmc   +1 more source

Genome-wide chromatin accessibility analysis unveils open chromatin convergent evolution during polyploidization in cotton. [PDF]

Proc Natl Acad Sci U S A, 2022
Han J, Lopez-Arredondo D, Yu G, Wang Y, Wang B, Wall SB, Zhang X, Fang H, Barragán-Rosillo AC, Pan X, Jiang Y, Chen J, Zhang H, Zhou BL, Herrera-Estrella L, Zhang B, Wang K.   +16 more
europepmc   +1 more source

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

Tracing the tissue origin of cell-free DNA through open chromatin footprint. [PDF]

Commun Biol
Li L, Li X, Li Y, Su F, Zhang Y, Tang Z, Sun J, Gao Y, Jin X, Zhang H.   +9 more
europepmc   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

TRAFICA: an open chromatin language model to improve transcription factor binding affinity prediction. [PDF]

Bioinformatics
Xu Y, Wang C, Xu K, Ding Y, Lyu A, Zhang L.   +5 more
europepmc   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source