Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Linked Open Government Data: Still a Viable Option for Sharing and Integrating Public Data?
Future InternetLinked Data (LD) principles, when applied to Open Government Data (OGD), aim to make government data accessible and interconnected, unlocking its full potential and facilitating widespread reuse.
Alfonso Quarati, Riccardo Albertoni
doaj +1 more source
Exploring the Quality of Dynamic Open Government Data Using Statistical and Machine Learning Methods. [PDF]
Sensors (Basel), 2022 Karamanou A +3 more
europepmc +1 more source
High-Resolution Satellite Data Open for Government Research [PDF]
U.S. satellite commercial imagery (CI) with resolution less than 1 meter is a common geospatial reference used by the public through Web applications, mobile devices, and the news media. However, CI use in the scientific community has not kept pace, even
Masek, Jeffrey G. +2 more
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Factors influencing open government data post-adoption in the public sector: The perspective of data providers. [PDF]
PLoS One, 2022 Mustapa MN, Hamid S, Md Nasaruddin FH.
europepmc +1 more source
Foreign technology summary of flight crucial flight control systems [PDF]
, 1984 A survey of foreign technology in flight crucial flight controls is being conducted to provide a data base for planning future research and technology programs.
Rediess, H. A.
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Analyzing the Impact of Macroeconomic Shocks on Public Debt Dynamics: An Application to the Czech Republic [PDF]
The global financial crisis and its ramification into the fiscal area have demonstrated the importance of regular assessment and monitoring of fiscal vulnerabilities, including the sustainability of sovereign debt.
Melecky, Ales, Melecky, Martin
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source