Results 61 to 70 of about 2,286,604 (339)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Predicting students’ academic progress and related attributes in first-year medical students: an analysis with artificial neural networks and Naïve Bayes

BMC Medical Education
Background Dropout and poor academic performance are persistent problems in medical schools in emerging economies. Identifying at-risk students early and knowing the factors that contribute to their success would be useful for designing educational ...
Diego Monteverde-Suárez, Patricia González-Flores, Roberto Santos-Solórzano, Manuel García-Minjares, Irma Zavala-Sierra, Verónica Luna de la Luz, Melchor Sánchez-Mendiola   +6 more
doaj   +1 more source

Innovating Pedagogy 2015: Open University Innovation Report 4 [PDF]

, 2015
This series of reports explores new forms of teaching, learning and assessment for an interactive world, to guide teachers and policy makers in productive innovation.
Adams, Anne, Alozie, N, Ferguson, Rebecca, FitzGerald, Elizabeth, Gaved, Mark, McAndrew, Patrick, Means, B, Remold, J, Rienties, Bart, Roschelle, J, Sharples, Mike, Vogt, K, Whitelock, Denise, Yarnall, L   +13 more
core  

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Evaluation of the redox alteration in Duchenne muscular dystrophy model mice using in vivo DNP-MRI

npj Imaging
Duchenne muscular dystrophy (DMD) is a genetic muscular disease and is the most common type of muscular dystrophy in Japan. Noninvasive magnetic resonance imaging (MRI) can be used for follow-up evaluation of myositis and muscular dystrophy, including ...
Hinako Eto, Masaharu Murata, Takahito Kawano, Yoko Tachibana, Abdelazim Elsayed Elhelaly, Yoshifumi Noda, Hiroki Kato, Masayuki Matsuo, Fuminori Hyodo   +8 more
doaj   +1 more source

Multi-sided platforms as catalysts for responsible innovation in healthcare: Patient Innovation as a case-study

Journal of Responsible Innovation
Healthcare systems face increasing pressure from aging populations, chronic diseases, and the demand for accessible, high-quality care. Yet many innovations fail to address the needs of vulnerable groups.
Gemma Tria, Maria João Jacinto, Margarida Oliveira, Helena Canhão, Pedro Oliveira   +4 more
doaj   +1 more source

Innovation through interaction - the concept of open innovation in theory and in practice [PDF]

, 2013
Open innovation is one of the most discussed topics connected to innovation, based not only on the search for new ideas and solutions but also on the emphasis for cooperation and the benefit of the diffusion of knowledge and dialogue.
Gwóźdź, Karolina
core  

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Recombination in the Open-Ended Value Landscape of Digital Innovation [PDF]

, 2018
Digital innovation introduces a new open-ended value landscape to anyone seeking to generate or capture new value. To understand this landscape, we distinguish between design recombination and use recombination, explore how they play out together, and ...
Arthur, Baldwin, Barrett, Benkler, Bharadwaj, Clark, DeLanda, Di Gangi, Eaton, Eisenmann, Eisenmann, El Sawy, Flath, Galunic, Garud, Gaskin, Gawer, Germonprez, Ghazawneh, Grover, Harry Scarbrough, Henfridsson, Henfridsson, Henfridsson, Huang, Joe Nandhakumar, Kallinikos, Katz, Kohli, Langlois, Lee, Lusch, Malhotra, Nambisan, Nambisan, Nandhakumar, Nikiforos Panourgias, Ola Henfridsson, Parker, Parker, Sanchez, Sarker, Sawy, Schilling, Schumpeter, Shapiro, Svahn, Tilson, Tiwana, Tiwana, Um, Von Hippel, Wareham, Yoo, Yoo, Yoo   +55 more
core   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source