Results 31 to 40 of about 1,544,831 (309)

Open issues in open world learning

AI Magazine
Abstract Meaningful progress has been made in open world learning (OWL), enhancing the ability of agents to detect, characterize, and incrementally learn novelty in dynamic environments. However, novelty remains a persistent challenge for agents relying on state‐of‐the‐art learning algorithms.
Steve Cruz, Katarina Doctor, Christopher Funk, Walter J. Scheirer   +3 more
openaire   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Coaching: an expensive conversation or a return on investment? [PDF]

International Journal of Evidence Based Coaching and Mentoring, 2013
The Collaborative Action Coaching for Leaders model (Cook, 2011) is designed for the transfer and sustainability of learning from the coaching session to outside that experience: it is a return on investment.
Janice Cook
doaj  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Classroom chronicles: through the eyeglasses of teachers at varying experience levels

Frontiers in Education, 2023
IntroductionTeachers face the intricate task of managing diverse classroom situations, directly affecting student learning outcomes. Many preservice and beginning teachers, however, find classroom management challenging.
Halszka Jarodzka, Sharisse van Driel, Sharisse van Driel, Leen Catrysse, Frank Crasborn   +4 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Heavy and trace metals in Zambian honey: Are consumers at risk?

Cogent Food & Agriculture
Honey is globally recognized for its a nutritious and medicinal value, but concerns are increasing over consumer health risks from heavy metal contamination.
Joseph Mphande, Sydney Chishimba, Julien Kabwe, Francis Kabwe Mwamba, Lawrencia Taimolo, Bwalya Mutale, John Simutenda, Emmanuel Nkweto, Kingdom Simfukwe, Justine Muchimba, Barbra Mpese, Mapenzi Mumwensi, Mainza Mapalo Hang’andu, Christoper Mulwanda   +13 more
doaj   +1 more source

Collaborative action research: the ethical challenges [PDF]

International Journal of Evidence Based Coaching and Mentoring, 2010
This article explores some of the ethical challenges that have been addressed primarily in the research design phase of a coaching doctoral research study.
Janice Cook
doaj  

The Effects of Gamification in Online Learning Environments: A Systematic Literature Review

Informatics, 2019
Gamification has recently been presented as a successful strategy to engage users, with potential for online education. However, while the number of publications on gamification has been increasing in recent years, a classification of its empirical ...
Alessandra Antonaci, Roland Klemke, Marcus Specht   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source