Results 51 to 60 of about 40,814,819 (270)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Vale do Côa rock art as linked open data: Application profile, schemas, and data [version 2; peer review: 1 approved, 2 approved with reservations]

Open Research Europe
Background The Côa Valley Archaeological Park, a UNESCO World Heritage site and the world’s most extensive example of open-air Paleolithic art, holds crucial data on its over 1,200 engraved rocks in the University of Minho’s proprietary 2ArchIS database.
Inês Miguel, Ana Baptista, Natália Botica, Juliana Galvão   +3 more
doaj   +1 more source

Glocal clinical registries: pacemaker registry design and implementation for global and local integration--methodology and case study.

PLoS ONE, 2013
BackgroundThe ability to apply standard and interoperable solutions for implementing and managing medical registries as well as aggregate, reproduce, and access data sets from legacy formats and platforms to advanced standard formats and operating ...
Kátia Regina da Silva, Roberto Costa, Elizabeth Sartori Crevelari, Marianna Sobral Lacerda, Caio Marcos de Moraes Albertini, Martino Martinelli Filho, José Eduardo Santana, João Ricardo Nickenig Vissoci, Ricardo Pietrobon, Jacson V Barros   +9 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Vale do Côa rock art as linked open data: Application profile, schemas, and data [version 3; peer review: 1 approved, 2 approved with reservations]

Open Research Europe
Background The Côa Valley Archaeological Park, a UNESCO World Heritage, preserves more than 1,200 engraved rocks spanning a long chronological sequence from Prehistory to the Contemporary period.
Inês Miguel, Ana Baptista, Natália Botica, Juliana Galvão   +3 more
doaj   +1 more source

Einführung in das PANDORA Linked Open Data Framework.

, 2017
A single abstract from the DHd-2017 Book of Abstracts.
Christopher Johnson, Jörg Wettlaufer
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Integration of linked open data in case-based reasoning systems [PDF]

, 2010
This paper discusses the opportunities of integrating Linked Open Data (LOD) resources into Case-Based Reasoning (CBR) systems. Upon the application domain travel medicine, we will exemplify how LOD can be used to fill three out of four knowledge ...
Bach, Kerstin, Sauer, Christian, Althoff, Klaus-Dieter   +2 more
core   +4 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source