Results 71 to 80 of about 47,560,035 (275)

A Research Agenda for Linked Closed Data

, 2011
While it is preferable that Linked Data is published without access or licence restrictions, there will always remain certain datasets which, perhaps due to financial considerations, cannot be published as Linked Open Data.
Gibbins, Nicholas, Black, Jennifer, Carr, Les, Cobden, Marcus, Shadbolt, Nigel   +4 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Statistical analysis of the owl:sameAs network for aligning concepts in the linking open data cloud [PDF]

, 2012
The massively distributed publication of linked data has brought to the attention of scientific community the limitations of classic methods for achieving data integration and the opportunities of pushing the boundaries of the field by experimenting this
Gianluca Correndo, Gibbins, Nicholas, Penta, Antonio, Nigel Shadbolt, Nicholas Gibbins, Antonio Penta, Correndo, Gianluca, Shadbolt, Nigel   +7 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Measuring the promise of open data: Development of the Impact Monitoring Framework [PDF]

, 2016
It is a challenge to measure the impact of releasing data to the public since the effects may not be directly linked to particular open data activities or substantial impact may only occur several years after publishing the data.
Stürmer, Matthias
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Linked Open Data: State-of-the-Art Mechanisms and Conceptual Framework

, 2020
Today, one of the state-of-the-art technologies that have shown its importance towards data integration and analysis is the linked open data (LOD) systems or applications. LOD constitute of machine-readable resources or mechanisms that are useful in describing data properties.
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Linkage of OGC WPS 2.0 to the e-Government Standard Framework in Korea: An Implementation Case for Geo-Spatial Image Processing

ISPRS International Journal of Geo-Information, 2017
There are many cases wherein services offered in geospatial sectors are integrated with other fields. In addition, services utilizing satellite data play important roles in daily life and in sectors such as environment and science.
Gooseon Yoon, Kwangseob Kim, Kiwon Lee
doaj   +1 more source