Results 91 to 100 of about 40,814,819 (270)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Analysing the development of the climate, land, energy, and water systems (CLEWs) modelling framework: a state-of-the-art review

Environmental Research: Climate
This comprehensive state-of-the-art literature review explores recent scientific developments in climate, land, energy, and water systems (CLEWs) modelling by systematically analysing 41 peer-reviewed studies published between 2020 and 2024.
Kane Alexander, Naomi Tan, Francesco Gardumi, Fernando Plazas-Nino, Kamaria Kuling, Eunice Ramos, Leigh Martindale, Vivien Foster   +7 more
doaj   +1 more source

Open data impact map

, 2015
The open data impact map is a searchable, centralized database of open data use cases from around the world. It is a collaborative effort that draws on previous studies, examples from an international network of Regional Supporters, an online survey ...
Center for Open Data Enterprise
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Combining numbers and perspectives: Using a Scale, Choice and Insight (SCI) approach for online survey research

Methodological Innovations
There is limited methodological guidance on systematically integrating numerical-style responses with open-ended questions in online surveys. This paper addresses this gap by presenting the Scale, Choice and Insight (SCI) approach, which applies to both ...
David Meechan
doaj   +1 more source

Publishing Linked Data - There is no One-Size-Fits-All Formula [PDF]

, 2012
Publishing Linked Data is a process that involves several design decisions and technologies. Although some initial guidelines have been already provided by Linked Data publishers, these are still far from covering all the steps that are necessary (from ...
Vila-Suero, Daniel, Corcho, Oscar, Vilches-Blazquez, LM., Poveda-Villalon, Maria, Villazón-Terrazas, Boris, Garijo, Daniel, Mora, Jose, Gómez-Pérez, A.   +7 more
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Construction, Deployment, and Usage of the Human Reference Atlas Knowledge Graph

Scientific Data
The Human Reference Atlas (HRA) for the healthy, adult body is being developed by a team of international, interdisciplinary experts across 25+ consortia.
Andreas Bueckle, Bruce W. Herr, Josef Hardi, Ellen M. Quardokus, Mark A. Musen, Katy Börner   +5 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source