Results 81 to 90 of about 47,560,035 (275)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Framework for Matching and Linking Large Ontologies [PDF]

, 2012
The Linked Open Data (LOD) initiative is the first large-scale attempt at realizing the Semantic Web vision of Tim Berners-Lee. As of September 2011, there are almost 300 knowledge bases linked together and available for public access through both web ...
Lukose, Dickson, Keizer, Johannes, Onn , Weng Kow, Niu, Michelle Lim Sien, Johannsen, Gudrun   +4 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Linked open data and Islandora

, 2014
Islandora is a digital asset management system that provides out-of-the-box repository solutions for a wide range of digital collections and research domains.
(), Tripp, Erin (author), MacKenzie, Mitch (author), Mark, Leggott (author)   +3 more
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

OpenBiodiv: A Knowledge Graph for Literature-Extracted Linked Open Data in Biodiversity Science

Publications, 2019
Hundreds of years of biodiversity research have resulted in the accumulation of a substantial pool of communal knowledge; however, most of it is stored in silos isolated from each other, such as published articles or monographs.
Lyubomir Penev, Mariya Dimitrova, Viktor Senderov, Georgi Zhelezov, Teodor Georgiev, Pavel Stoev, Kiril Simov   +6 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

From Data Complexity to User Simplicity: A Framework for Linked Open Data Reconciliation and Serendipitous Discovery

CoRR
This article introduces a novel software solution to create a Web portal to align Linked Open Data sources and provide user-friendly interfaces for serendipitous discovery. We present the Polifonia Web portal as a motivating scenario and case study to address research problems such as data reconciliation and serving generous interfaces in the music ...
Marco Grasso, Giulia Renda, Marilena Daquino   +2 more
openaire   +4 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Analysing the development of the climate, land, energy, and water systems (CLEWs) modelling framework: a state-of-the-art review

Environmental Research: Climate
This comprehensive state-of-the-art literature review explores recent scientific developments in climate, land, energy, and water systems (CLEWs) modelling by systematically analysing 41 peer-reviewed studies published between 2020 and 2024.
Kane Alexander, Naomi Tan, Francesco Gardumi, Fernando Plazas-Nino, Kamaria Kuling, Eunice Ramos, Leigh Martindale, Vivien Foster   +7 more
doaj   +1 more source