Results 91 to 100 of about 1,007,234 (319)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Detecting Coordination Problems in Collaborative Software Development Environments [PDF]

, 2008
Software development is rarely an individual effort and generally involves teams of developers collaborating to generate good reliable code. Among the software code there exist technical dependencies that arise from software components using services ...
Amrit, Chintan, Hillegersberg, Jos van
core   +5 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Research on a comprehensive evaluation method for truck-shovel coordination efficiency in open-pit coal mine stripping faces

Gong-kuang zidonghua
In the single-bucket–truck process system of open-pit coal mines, coordinated operations between trucks and electric shovels often experience phenomena such as "trucks waiting for shovels" or "shovels waiting for trucks", leading to decreased ...
CHAI Senlin, LIU Guangwei, SONG Jiachen, SONG Qun, NIU Xiyang, ZHANG Linbo   +5 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Research on Adaptive Cycle Engine Mode Transition Control Method

Energies
Mode transition is an important dynamic process of an adaptive cycle engine (ACE). In order to obtain a smooth mode transition process, the closed-loop controller is designed based on the strong robust augmented linear quadric regulator (ALQR) method ...
Xingyu Zhao, Qiuhong Li, Shuwei Pang, Zhaohui Xue, Daming Deng, Feng Lu   +5 more
doaj   +1 more source

How Legitimate is the Open Method of Co‐ordination?* [PDF]

JCMS: Journal of Common Market Studies, 2008
AbstractThis article argues that the OMC's legitimacy can be improved only by strengthening parliamentary channels of input‐legitimacy since output‐legitimacy alone is inappropriate and cannot be achieved without input‐legitimacy. In addition, concepts and practices of direct ‘stakeholder’ participation currently applied within the OMC are insufficient
openaire   +2 more sources

Policy learning in Europe: The 'open method of coordination' and laboratory federalism [PDF]

, 2005
The Open Method of Coordination (OMC) is a new governance method applied in the European Union to policy fields where the main competences still rest with the member states.
Eckardt, Martina, Kerber, Wolfgang
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Відкритий метод координації як спосіб співпраці Європейського Союзу з країнами-учасницями [PDF]

, 2012
У багатьох галузях політики державам-членам Європейського Союзу надається право реалізовувати свою національну політику паралельно загальноєвропейській.
Najdych, M. A., Найдич, Марина Анатоліївна   +1 more
core