Results 41 to 50 of about 330,176 (256)

Developing a Pan-European Open Science Training Landscape

open access: yesABI Technik, 2023
Abstract In an environment designed to increasingly enable Open Science, not all researchers and research supporting units have the required competences. Moreover, there is a lack of clear data professionals’ profiles and corresponding career paths, and a high degree of fragmentation in training resources.
Dr. Paolo Budroni   +3 more
openaire   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Journal Evaluation Model of the Pracownia Naukoznawstwa IHN PAN: Update of Journal Evaluation Rules and Journal Scoring in the History of Science in 2023

open access: yesStudia Historiae Scientiarum, 2023
The article presents: a) updating the rules for evaluating journals in the evaluation model developed in the Pracownia Naukoznawstwa IHN PAN (Science Studies and Science-of-Science Unit of the Institute for History of Science, Polish Academy of Sciences)
Michał Kokowski
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Genome Sequencing and Pan-Genome Analysis of 23 Corallococcus spp. Strains Reveal Unexpected Diversity, With Particular Plasticity of Predatory Gene Sets

open access: yesFrontiers in Microbiology, 2018
Corallococcus is an abundant genus of predatory soil myxobacteria, containing two species, C. coralloides (for which a genome sequence is available) and C. exiguus.
Paul G. Livingstone   +2 more
doaj   +1 more source

Pan-Africa passport to open up borders

open access: yesAfrica Renewal, 2016
The image of Rwandan President Paul Kagame and Chadian President Idriss Deby proudly holding the first two copies of the newly launched pan-African passport at the African Union (AU) summit in the Rwandan capital Kigali this month marked the type of historic moment rarely seen at such gatherings, where outcomes are often measured in declarations or ...
openaire   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

Effects of seat pan and pelvis angles on the occupant response in a reclined position during a frontal crash.

open access: yesPLoS ONE, 2021
Current highly automated vehicle concepts include reclined seat layouts that could allow occupants to relax during the drive. The main objective of this study was to investigate the effects of seat pan and pelvis angles on the kinematics and injury risk ...
Cyrille Grébonval   +4 more
doaj   +1 more source

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