Results 51 to 60 of about 510,176 (216)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Pan-European open building footprints: analysis and comparison in selected countries [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information SciencesThis paper presents a comprehensive analysis of four non-governmental open building datasets available at the European Union (EU) level, namely OpenStreetMap (OSM), EUBUCCO, Digital Building Stock Model (DBSM) and Microsoft’s Global ML Building ...
M. Minghini +2 more
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
PLoS ONECorynebacterium glutamicum is a non-pathogenic species of the Corynebacteriaceae family. It has been broadly used in industrial biotechnology for the production of valuable products.
Md Shahedur Rahman +2 more
doaj +1 more source
BMC Evolutionary Biology, 2019 Background The genus Streptococcus comprises pathogens that strongly influence the health of humans and animals. Genome sequencing of multiple Streptococcus strains demonstrated high variability in gene content and order even in closely related strains ...
Pavel V. Shelyakin +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Does evaporation paradox exist in China? [PDF]
Hydrology and Earth System Sciences, 2009 One expected consequence of global warming is the increase in evaporation. However, lots of observations show that the rate of evaporation from open pans of water has been steadily decreasing all over the world in the past 50 years.
Z. T. Cong, D. W. Yang, G. H. Ni
doaj
Acquisition of terrestrial life by human ancestors influenced by forest microclimate
Scientific Reports, 2017 Bipedalism, terrestriality and open habitat were thought to be linked to each other in the course of human evolution. However, recent paleontological evidence has revealed that early hominins evolved in a wooded, humid environment.
Hiroyuki Takemoto
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2017 Piscirickettsia salmonis is the etiological agent of salmonid rickettsial septicemia, a disease that seriously affects the salmonid industry. Despite efforts to genomically characterize P.
Guillermo Nourdin-Galindo +24 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source